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Abstract：
Asbestos is the primary known cause of malignant mesothelioma. Some cosmetic talc products have been shown to contain asbestos. Recently, repeated exposures to cosmetic talc have been implicated as a cause of mesothelioma.
Seventy-five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum powders, were reviewed in medical-legal consultation. Out of the 75 cases, 11 were examined for asbestiform fibers.
All subjects had pathologically confirmed malignant mesothelioma. The mean age at diagnosis was 61 ± 17 years. The mean latency from exposure to diagnosis was 50 ± 13 years. The mean exposure duration was 33 ± 16 years. Four mesotheliomas (5%) occurred in individuals working as barbers/cosmetologists, or in a family member who swept the barber shop. Twelve (16%) occurred in individuals less than 45 years old (10 females; 2 males). Forty-eight mesotheliomas were pleural (40 females; 8 males), 23 were peritoneal (21 females; 2 males). Two presented with concomitant pleural and peritoneal disease. There was one pericardial, and one testicular mesothelioma. The majority (51) were of the epithelioid histological subtype, followed by 13 biphasic, 8 sarcomatoid, 2 lymphohistiocytoid, and 1 poorly differentiated. Of the 11 individuals whose nontumorous tissues were analyzed for the presence of asbestiform fibers, all showed the presence of anthophyllite and/or tremolite asbestos.
Mesotheliomas can develop following exposures to cosmetic talcum powders. These appear to be attributable to the presence of anthophyllite and tremolite contaminants in cosmetic talcum powder.
Seventy-five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum powders, were reviewed in medical-legal consultation. Out of the 75 cases, 11 were examined for asbestiform fibers.
All subjects had pathologically confirmed malignant mesothelioma. The mean age at diagnosis was 61 ± 17 years. The mean latency from exposure to diagnosis was 50 ± 13 years. The mean exposure duration was 33 ± 16 years. Four mesotheliomas (5%) occurred in individuals working as barbers/cosmetologists, or in a family member who swept the barber shop. Twelve (16%) occurred in individuals less than 45 years old (10 females; 2 males). Forty-eight mesotheliomas were pleural (40 females; 8 males), 23 were peritoneal (21 females; 2 males). Two presented with concomitant pleural and peritoneal disease. There was one pericardial, and one testicular mesothelioma. The majority (51) were of the epithelioid histological subtype, followed by 13 biphasic, 8 sarcomatoid, 2 lymphohistiocytoid, and 1 poorly differentiated. Of the 11 individuals whose nontumorous tissues were analyzed for the presence of asbestiform fibers, all showed the presence of anthophyllite and/or tremolite asbestos.
Mesotheliomas can develop following exposures to cosmetic talcum powders. These appear to be attributable to the presence of anthophyllite and tremolite contaminants in cosmetic talcum powder.
摘要：
石棉是恶性间皮瘤的主要已知原因。一些化妆品滑石产品已显示含有石棉。最近,反复接触化妆品滑石粉被认为是间皮瘤的一个原因。
75人（64名女性，11名男性）患有恶性间皮瘤，其唯一已知的接触石棉是反复接触化妆品滑石粉，在医学法律咨询中进行了审查。在75个案例中，检查了11的石棉纤维。
所有受试者均有病理证实的恶性间皮瘤。诊断时的平均年龄为61±17岁。从暴露到诊断的平均潜伏期为50±13年。平均暴露时间为33±16年。四个间皮瘤（5％）发生在作为理发师/美容师的个人中，或者是扫理发店的家庭成员。12例（16％）发生在45岁以下的个体中（10例女性；2例男性）。48个间皮瘤为胸膜（40个女性；8个男性），腹膜23例（女性21例；男性2例）。其中2例伴有胸膜和腹膜疾病。有一个心包,还有一个睾丸间皮瘤.大多数（51）是上皮样组织学亚型，其次是13双相，8肉瘤样，2淋巴组织细胞样，1分化差。在对11个非肿瘤组织进行分析的个体中，均显示存在直闪石和/或透闪石石棉。
接触化妆品滑石粉后，间皮瘤会发展。这些似乎归因于化妆品滑石粉中存在直闪石和透闪石污染物。
75人（64名女性，11名男性）患有恶性间皮瘤，其唯一已知的接触石棉是反复接触化妆品滑石粉，在医学法律咨询中进行了审查。在75个案例中，检查了11的石棉纤维。
所有受试者均有病理证实的恶性间皮瘤。诊断时的平均年龄为61±17岁。从暴露到诊断的平均潜伏期为50±13年。平均暴露时间为33±16年。四个间皮瘤（5％）发生在作为理发师/美容师的个人中，或者是扫理发店的家庭成员。12例（16％）发生在45岁以下的个体中（10例女性；2例男性）。48个间皮瘤为胸膜（40个女性；8个男性），腹膜23例（女性21例；男性2例）。其中2例伴有胸膜和腹膜疾病。有一个心包,还有一个睾丸间皮瘤.大多数（51）是上皮样组织学亚型，其次是13双相，8肉瘤样，2淋巴组织细胞样，1分化差。在对11个非肿瘤组织进行分析的个体中，均显示存在直闪石和/或透闪石石棉。
接触化妆品滑石粉后，间皮瘤会发展。这些似乎归因于化妆品滑石粉中存在直闪石和透闪石污染物。
