BGN / TLR4 / NF - B 介导结肠癌细胞中免疫抑制性 Siglec 配体的表观遗传沉默。
关键词: BGN NF-B SLC26A2 ST6GalNAc6 Siglec-7 TLR disialyl Lewisa sialyl 6-sulfo Lewisx
Mesh : Base Sequence Biglycan / metabolism Carcinogenesis / pathology Cell Line, Tumor Colonic Neoplasms / genetics pathology Epigenesis, Genetic Gene Silencing Humans Immunosuppression Therapy Ligands NF-kappa B / metabolism Polycomb Repressive Complex 2 / metabolism Promoter Regions, Genetic / genetics Sialic Acid Binding Immunoglobulin-like Lectins / metabolism Sialyltransferases / genetics metabolism Sulfate Transporters / genetics metabolism Toll-Like Receptor 4 / metabolism
来 源:
DOI:10.3390/cells9020397
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