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Abstract：
The emergence and spread of antibiotic-resistant bacteria constitute a critical issue for modern medicine. Patients with antibiotic-resistant bacterial infections consume more healthcare resources and have worse clinical outcomes than patients with antibiotic-sensitive bacterial infections. Phages are natural predators of bacteria and may therefore be a source of useful antibacterial drugs. Phage therapy possess availability for oral administration, penetration through the bacteria cell wall, and eradication bacterial biofilms. All of these advantages give phage therapy the possibility to turn into applications for infectious diseases. In this mini-review, we focus on the brief history of lytic phage therapy, the life cycles of lytic phages and the therapeutic effects of lytic phages.
摘要：
抗生素抗性细菌的出现和传播构成了现代医学的关键问题。与抗生素敏感细菌感染患者相比，抗生素耐药细菌感染患者消耗更多的医疗资源，临床结果更差。噬菌体是细菌的天然捕食者，因此可能是有用的抗菌药物的来源。噬菌体疗法具有口服给药的可用性，穿透细菌细胞壁，和根除细菌生物膜。所有这些优点使噬菌体疗法有可能应用于感染性疾病。在这个小型审查中，我们专注于裂解性噬菌体疗法的简史，裂解噬菌体的生命周期和裂解噬菌体的治疗效果。
