PDF(Pubmed)
Abstract：
Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results - Mean difference 95% CI - -0.02 [-0.61,0.57]. Meta-analysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals -5.05 [-7.68, -2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals.
摘要：
在实验性梗塞之前进行锻炼可能对心脏产生有益影响。这项研究的目的是分析对心肌梗死前运动过的动物的研究，并通过系统评价和荟萃分析来检查任何益处。MEDLINE数据库,谷歌学者，并咨询了Cochrane.我们分析了1978年1月至2018年11月发表的文章。在总共858篇文章中，这篇评论中选择了13份手稿。当动物在实验性梗死前运动时，死亡率降低了，梗死面积缩小,改善心脏功能，以及表现出心脏保护作用的基因和蛋白质之间更好的分子平衡。分析心脏重量/体重，我们观察到以下结果-平均差95%CI--0.02[-0.61,0.57]。梗死面积（占左心室的百分比）的荟萃分析显示，在心肌梗死前运动的动物中，梗死面积有统计学意义的减少。与久坐的动物相比-5.05[-7.68，-2.40]。射血分数分析，通过回声(%)测量，揭示了在心肌梗死前锻炼的动物表现出更高和统计学上显著的指标，与久坐的动物相比8.77[3.87,13.66]。我们得出的结论是，在实验性心肌梗塞之前进行的运动会给动物带来心脏益处。
