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Abstract：
OBJECTIVE: This study aimed to assess the presence of sleep disorders in patients with epilepsy and to analyse their association with seizure control.
METHODS: We performed a cross-sectional study of patients with epilepsy, recruited consecutively between September 2017 and December 2018. Patients were classified as having good seizure control (no seizures in the last 4 weeks) or poor seizure control (at least one seizure in the last 4 weeks). We performed intergroup comparisons for demographic and clinical data, insomnia (Insomnia Severity Index [ISI]), excessive daytime sleepiness (Epworth Sleepiness Scale [ESS]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), depression (Beck Depression Inventory-II [BDI-II]), and quality of life (Quality of Life in Epilepsy Inventory-10 [QOLIE-10]).
RESULTS: The sample included a total of 123 patients, of whom 31.7% had excessive daytime sleepiness (ESS≥10), 50.4% had insomnia (ISI≥10), and 53.6% had poor sleep quality (PSQI≥5). According to our multivariate analysis, presence of seizures was associated with unemployment (odds ratio [OR]=4.7; 95% confidence interval [CI], 1.36-19.2; P=.02), a higher number of antiepileptic drugs (OR=5.87; 95% CI, 1.81-27.1; P<.001), insomnia (OR=1.9; 95% CI, 1.1-9.3; P=.04), and poor sleep quality (OR=2.8; 95% CI, 1.9-10.32; P=.01).
CONCLUSIONS: Sleep disorders are common in patients with epilepsy. Insomnia and poor sleep quality were associated with poor seizure control. These findings support the hypothesis that sleep disorders constitute a significant comorbidity of epilepsy, especially in patients with poor seizure control.
METHODS: We performed a cross-sectional study of patients with epilepsy, recruited consecutively between September 2017 and December 2018. Patients were classified as having good seizure control (no seizures in the last 4 weeks) or poor seizure control (at least one seizure in the last 4 weeks). We performed intergroup comparisons for demographic and clinical data, insomnia (Insomnia Severity Index [ISI]), excessive daytime sleepiness (Epworth Sleepiness Scale [ESS]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), depression (Beck Depression Inventory-II [BDI-II]), and quality of life (Quality of Life in Epilepsy Inventory-10 [QOLIE-10]).
RESULTS: The sample included a total of 123 patients, of whom 31.7% had excessive daytime sleepiness (ESS≥10), 50.4% had insomnia (ISI≥10), and 53.6% had poor sleep quality (PSQI≥5). According to our multivariate analysis, presence of seizures was associated with unemployment (odds ratio [OR]=4.7; 95% confidence interval [CI], 1.36-19.2; P=.02), a higher number of antiepileptic drugs (OR=5.87; 95% CI, 1.81-27.1; P<.001), insomnia (OR=1.9; 95% CI, 1.1-9.3; P=.04), and poor sleep quality (OR=2.8; 95% CI, 1.9-10.32; P=.01).
CONCLUSIONS: Sleep disorders are common in patients with epilepsy. Insomnia and poor sleep quality were associated with poor seizure control. These findings support the hypothesis that sleep disorders constitute a significant comorbidity of epilepsy, especially in patients with poor seizure control.
摘要：
目的：本研究旨在评估癫痫患者睡眠障碍的存在，并分析其与癫痫发作控制的关系。
方法：我们对癫痫患者进行了横断面研究，在2017年9月至2018年12月期间连续招募。患者被分类为具有良好的癫痫发作控制(在过去4周内没有癫痫发作)或较差的癫痫发作控制(在过去4周内至少有一次癫痫发作)。我们对人口统计学和临床数据进行了组间比较，失眠（失眠严重程度指数[ISI]），白天过度嗜睡（Epworth嗜睡量表[ESS]），睡眠质量（匹兹堡睡眠质量指数[PSQI]），抑郁症(贝克抑郁量表-II[BDI-II])，和生活质量(癫痫生活质量量表-10[QOLIE-10])。
结果：样本共包括123名患者，其中31.7%的人白天嗜睡过度(ESS≥10)，50.4%有失眠（ISI≥10），53.6%的人睡眠质量差(PSQI≥5)。根据我们的多变量分析，癫痫发作的存在与失业相关(比值比[OR]=4.7；95%置信区间[CI]，1.36-19.2；P=.02)，抗癫痫药物的数量较高（OR=5.87；95％CI，1.81-27.1；P<.001），失眠（OR=1.9；95%CI，1.1-9.3；P=0.04），睡眠质量差（OR=2.8；95%CI，1.9-10.32；P=0.01）。
结论：睡眠障碍在癫痫患者中很常见。失眠和睡眠质量差与癫痫发作控制不良有关。这些发现支持以下假设：睡眠障碍构成了癫痫的重要共病，尤其是癫痫控制不佳的患者。
方法：我们对癫痫患者进行了横断面研究，在2017年9月至2018年12月期间连续招募。患者被分类为具有良好的癫痫发作控制(在过去4周内没有癫痫发作)或较差的癫痫发作控制(在过去4周内至少有一次癫痫发作)。我们对人口统计学和临床数据进行了组间比较，失眠（失眠严重程度指数[ISI]），白天过度嗜睡（Epworth嗜睡量表[ESS]），睡眠质量（匹兹堡睡眠质量指数[PSQI]），抑郁症(贝克抑郁量表-II[BDI-II])，和生活质量(癫痫生活质量量表-10[QOLIE-10])。
结果：样本共包括123名患者，其中31.7%的人白天嗜睡过度(ESS≥10)，50.4%有失眠（ISI≥10），53.6%的人睡眠质量差(PSQI≥5)。根据我们的多变量分析，癫痫发作的存在与失业相关(比值比[OR]=4.7；95%置信区间[CI]，1.36-19.2；P=.02)，抗癫痫药物的数量较高（OR=5.87；95％CI，1.81-27.1；P<.001），失眠（OR=1.9；95%CI，1.1-9.3；P=0.04），睡眠质量差（OR=2.8；95%CI，1.9-10.32；P=0.01）。
结论：睡眠障碍在癫痫患者中很常见。失眠和睡眠质量差与癫痫发作控制不良有关。这些发现支持以下假设：睡眠障碍构成了癫痫的重要共病，尤其是癫痫控制不佳的患者。
