低叶酸浓度影响神经管缺陷中的错配修复缺陷。
关键词: DNA repair H3K36me3 Msh6 folate insufficiency histone modification mismatch repair deficiency neural tube closure neural tube defect rare variant sequencing
Mesh : DNA Mismatch Repair / genetics Disease Susceptibility Folic Acid / metabolism Folic Acid Deficiency / complications metabolism Genetic Variation Histones / metabolism Humans Neural Tube Defects / etiology metabolism
来 源:
DOI:10.2217/epi-2019-0279
PDF(Sci-hub)