False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia.

HIV 感染患者经培养证实的隐球菌血症的血清隐球菌抗原侧流测定结果假阴性。

• 发表时间: Dec 2019
• 来源期刊: Med Mycol Case Rep
• DOI: 10.1016/j.mmcr.2019.10.009
• PMID: 31737475
• 文章类型: Case Reports
• 作者列表: Borges MASB,Araújo Filho JA,Soares RBA,Vidal JE,Turchi MD

关键词: AIDS; Cryptococcosis; False negative reaction; Fungal antigens; Prozone effect

Abstract

The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant.

摘要

隐球菌荚膜抗原（CrAg）的检测非常敏感和特异，然而，已经报道了假阴性结果，大部分在脑脊液中.我们报告了一例HIV感染患者的CD4=42细胞/mL，虚弱，阴性血清CrAg侧流测定（LFA）和培养证实的隐球菌血症。尽管LFA的准确性很高，假阴性结果是可能的。仔细的临床评估和密切的随访是相关的。