Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.

• 影响指数: 1.282
• 发表时间: Mar 2020 1
• 来源期刊: Intern Med
• DOI: 10.2169/internalmedicine.3626-19
• PMID: 31735790
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Akagi M,Umeda M,Hashisako M,Hara K,Tsuji S,Endo Y,Takatani A,Shimizu T,Fukui S,Koga T,Kawashiri SY,Iwamoto N,Igawa T,Ichinose K,Tamai M,Nakamura H,Origuchi T,Niino D,Kawakami A

关键词: drop head syndrome; mixed connective tissue disease; myositis; neck extensor muscles

Mesh: Antibodies, Antinuclear / blood; Creatine Kinase / blood; Female; Glucocorticoids / therapeutic use; Humans; Middle Aged; Mixed Connective Tissue Disease / complications drug therapy; Muscle Weakness / etiology; Myositis / drug therapy; Neck Muscles / pathology; Prednisolone / therapeutic use; Raynaud Disease / complications

Abstract

A 54-year-old woman developed drop head syndrome (DHS), Raynaud\'s phenomenon and creatine kinase (CK) elevation. She did not meet the international classification criteria of dermatomyositis/polymyositis, as we observed no muscle weakness, grasping pain or electromyography abnormality in her limbs, and anti-aminoacyl tRNA synthetase (ARS) antibody was negative. Cervical magnetic resonance imaging and a muscle biopsy of the trapezius muscle revealed myositis findings as the only clinical observations in muscle. These findings, along with her anti-U1-ribonucleoprotein (RNP) antibody positivity and leukopenia, resulted in a diagnosis of mixed connective tissue disease (MCTD). Prednisolone treatment significantly improved her myositis. To our knowledge, this is the first report of DHS as the only muscle complication of MCTD.