%0 Case Reports
%T Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.
%A Akagi M
%A Umeda M
%A Hashisako M
%A Hara K
%A Tsuji S
%A Endo Y
%A Takatani A
%A Shimizu T
%A Fukui S
%A Koga T
%A Kawashiri SY
%A Iwamoto N
%A Igawa T
%A Ichinose K
%A Tamai M
%A Nakamura H
%A Origuchi T
%A Niino D
%A Kawakami A
%J Intern Med
%V 59
%N 5
%D Mar 2020 1
%M 31735790
%F 1.282
%R 10.2169/internalmedicine.3626-19
%X A 54-year-old woman developed drop head syndrome (DHS), Raynaud's phenomenon and creatine kinase (CK) elevation. She did not meet the international classification criteria of dermatomyositis/polymyositis, as we observed no muscle weakness, grasping pain or electromyography abnormality in her limbs, and anti-aminoacyl tRNA synthetase (ARS) antibody was negative. Cervical magnetic resonance imaging and a muscle biopsy of the trapezius muscle revealed myositis findings as the only clinical observations in muscle. These findings, along with her anti-U1-ribonucleoprotein (RNP) antibody positivity and leukopenia, resulted in a diagnosis of mixed connective tissue disease (MCTD). Prednisolone treatment significantly improved her myositis. To our knowledge, this is the first report of DHS as the only muscle complication of MCTD.