关键词: Aspergillus species Chemotaxis Chronic granulomatous disease Chédiak–Higashi Syndrome Hyperimmunoglobulin E Leukocyte adhesion deficiency Myeloperoxidase NADPH oxidase Neutrophil granule Staphylococcus aureus β2 integrin

Mesh : Animals Biomarkers Cell Adhesion / immunology Cell Degranulation / genetics immunology Chemotaxis / genetics immunology Disease Management Disease Susceptibility Humans Immunoglobulin E / immunology Leukocyte Disorders / diagnosis etiology metabolism Molecular Diagnostic Techniques Mutation Neutrophils / immunology metabolism Oxidation-Reduction Phagocytosis / immunology

来  源:   DOI:10.1007/978-1-0716-0154-9_2

Abstract:
Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak-Higashi Syndrome, neutrophil specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.
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