青蒿琥酯和 HDAC 抑制剂通过协同上调 ALAS1 表达提高血红素合成的协同抗肿瘤活性。
关键词: ALA, 5-aminolevulinic acid ALAD, 5-aminolevulinate dehydratase ALAS, 5-aminolevulinate synthase ALAS1 ARS, artesunate ART, artemisinin Antitumor Artesunate CCK-8, cell counting kit 8 CI, combination index CMCNa, carboxymethyl cellulose DHA, dihydroartemisinin DMAB, (dimethylamino)benzaldehyde FECH, ferrochelatase GSDME, gasdermin E HDAC inhibitor HDAC, histone deacetylase HDACi, HDAC inhibitor HMBS, hydroxymethylbilane synthase Heme KD, knockdown KO, knockout LBH589, panobinostat PDT, photodynamic therapy PI, propidium iodide PpIX, protoporphyrin IX ROS, reactive oxygen species SA, succinyl acetone SAHA, vorinostat WT, wild-type sgRNA, single guide RNA
来 源:
DOI:10.1016/j.apsb.2019.05.001
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