关键词: Adaptation posologique Automédication Chronic renal disease Dosage adjustment Maladie rénale chronique Medicinal product Médicament Pharmacien Pharmacist Prevention Prévention Recommandation Recommendation Selfmedication

Mesh : Anti-Inflammatory Agents, Non-Steroidal / adverse effects Contrast Media / adverse effects Food-Drug Interactions Health Education Herb-Drug Interactions Humans Iatrogenic Disease / epidemiology prevention & control Plant Preparations / adverse effects Practice Guidelines as Topic Proton Pump Inhibitors / adverse effects Renal Insufficiency, Chronic / chemically induced epidemiology prevention & control Risk Factors Self Medication

来  源:   DOI:10.1016/j.nephro.2019.04.003   PDF(Sci-hub)

Abstract:
Ten percent of the world\'s population is affected by chronic kidney disease that can lead to kidney failure. In France, nearly three million people are concerned, half of whom are undiagnosed, 85,000 people are on dialysis or waiting for a kidney transplant. Each year, 11,000 new diagnoses of severe renal failure are made, one third of which had not been treated before. Kidney failure is constantly increasing due to the aging of the population and the resurgence of chronic diseases, including obesity and cardiovascular diseases such as high blood pressure and diabetes, two conditions that impair renal function. The pharmacist, a local actor, is well placed to help patients adhere to their treatment and manage it to the best of their quality of life. It is up to the pharmacist to check the dosages according to the degree of renal involvement, ideally noted on the prescription or, failing that, by asking the patient the results of his recent biological examinations. The consultation of the pharmaceutical file and, ultimately, the shared medical file, will make it possible, in a concerted management of the patient\'s care pathway, to also detect possible drug interactions. By dispensing the prescribed drugs, the pharmacist can also warn against those known to be known for their nephrotoxicity, especially nonsteroidal anti-inflammatory drugs. In the case of over-the-counter products, the pharmacist may discourage a person at risk from taking certain drugs containing nonsteroidal anti-inflammatory drugs, including aspirin and ibuprofen. Because of their potential renal toxicity, the pharmacist is competent to alert, especially on certain food supplements, herbal products, and is legitimate to participate in screening campaigns.
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