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Abstract：
Nutritional deficiencies often precede the diagnosis of cystic fibrosis (CF) in infants, and occur at a stage where the rapidly developing brain is more vulnerable to insult. We aim to compare fat-soluble nutrient status of newly diagnosed non-screened infants with CF to that of healthy infants, and explore the association with neurodevelopment evaluated by electroencephalography (EEG). Our results show that CF infants had lower levels of all fat-soluble vitamins and docosahexaenoic acid (DHA) compared to controls. The auditory evoked potential responses were higher in CF compared to controls whereas the visual components did not differ between groups. DHA levels were correlated with auditory evoked potential responses. Although resting state frequency power was similar between groups, we observed a negative correlation between DHA levels and low frequencies. This study emphasizes the need for long-term neurodevelopmental follow-up of CF infants and pursuing intervention strategies in the future.
摘要：
营养缺乏通常在婴儿囊性纤维化（CF）的诊断之前，并且发生在快速发育的大脑更容易受到侮辱的阶段。我们的目的是比较新诊断的非筛查CF婴儿与健康婴儿的脂溶性营养状况。并探讨脑电图（EEG）评估与神经发育的关系。我们的结果表明，与对照组相比，CF婴儿的所有脂溶性维生素和二十二碳六烯酸（DHA）水平较低。CF中的听觉诱发电位反应高于对照组，而视觉成分在组间没有差异。DHA水平与听觉诱发电位反应相关。尽管静息状态频率功率在组间相似，我们观察到DHA水平与低频之间呈负相关。这项研究强调了对CF婴儿进行长期神经发育随访的必要性，并在未来寻求干预策略。
