Loss of Fingerprints as a Side Effect of Capecitabine Therapy: Case Report and Literature Review.

• 影响指数: 4.938
• 发表时间: Feb 2020 7
• 来源期刊: Oncol Res
• DOI: 10.3727/096504019X15605078731913
• PMID: 31558182
• 文章类型: Case Reports
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Zhao J,Zhang X,Cui X,Wang D,Zhang B,Ban L

Mesh: Aged; Antimetabolites, Antineoplastic / administration & dosage adverse effects; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Breast Neoplasms / drug therapy; Capecitabine / administration & dosage adverse effects; Dermatoglyphics; Docetaxel / administration & dosage; Female; Hand-Foot Syndrome / etiology; Humans

Abstract

Hand-foot syndrome (HFS) is the main side effect of capecitabine and affects the compression zones of the body such as the palms and soles, causing numbness, paresthesias, skin swelling or erythema, scaling, chapping, hard nodule-like blisters, and severe pain. Loss of fingerprints is also observed in some cases. Severe cases of HFS are common in the review of clinical reports. However, loss of fingerprints has not received significant attention. Two reported cases of loss of fingerprints in The New England Journal of Medicine and The BMJ have drawn attention to this side effect of capecitabine. Loss of fingerprints has a serious impact on patients\' daily life, especially on personal identification. This report describes a patient who lost her fingerprints during the early stage of chemotherapy. Our aim is to draw the medical profession\'s attention to this problem.