Disseminated Emergomycosis in a Person with HIV Infection, Uganda.

HIV 感染者中的播散性毛癣 ，乌干达。

• 影响指数: 16.126
• 发表时间: 09 2019
• 来源期刊: Emerg Infect Dis
• DOI: 10.3201/eid2509.181234
• PMID: 31441766
• 文章类型: Case Reports
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Rooms I,Mugisha P,Gambichler T,Hadaschik E,Esser S,Rath PM,Haase G,Wilmes D,McCormick-Smith I,Rickerts V

关键词: Broad-range fungal PCR; Emergomycosis; FFPE; Formalin-fixed paraffin-embedded biopsy; Fungi; HIV/AIDS and other retroviruses; Uganda

Mesh: Adult; Antifungal Agents / therapeutic use; Chrysosporium / genetics isolation & purification; Diagnosis, Differential; Female; HIV Infections; Humans; Itraconazole / therapeutic use; Mycoses / diagnosis drug therapy microbiology; Polymerase Chain Reaction; Uganda

Abstract

We describe emergomycosis in a patient in Uganda with HIV infection. We tested a formalin-fixed, paraffin-embedded skin biopsy to identify Emergomyces pasteurianus or a closely related pathogen by sequencing broad-range fungal PCR amplicons. Results suggest that emergomycosis is more widespread and genetically diverse than previously documented. PCR on tissue blocks may help clarify emergomycosis epidemiology.

摘要

我们描述了乌干达HIV感染患者的胚芽病。我们测试了福尔马林固定的，石蜡包埋的皮肤活检，通过对广谱真菌PCR扩增子进行测序，以鉴定巴斯德氏菌或密切相关的病原体。结果表明，与以前记录的相比，胚芽菌病更为广泛和遗传多样性。在组织块上进行PCR可能有助于阐明紧急真菌病的流行病学。