关键词： Cystobasidium laryngis anti-inflammatory activity deep-sea sediment marine yeast-like fungi phenazine derivatives saphenic acid

Mesh ： Animals Anti-Inflammatory Agents / chemistry pharmacology Aquatic Organisms / chemistry Cell Line Fungi / chemistry Lipopolysaccharides / pharmacology Macrophages / drug effects Mice Nitric Oxide / metabolism Phenazines / chemistry pharmacology RAW 264.7 Cells Yeasts / chemistry

来  源：   DOI：10.3390/md17080482   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Three new phenazine derivatives (1-3), along with known compounds (4-7) of saphenic acid derivatives, were isolated from a deep-sea sediment-derived yeast-like fungus Cystobasidium larynigs collected from the Indian Ocean. The structures of the new compounds (1-3) were determined by analysis of spectroscopic data, semi-synthesis and comparison of optical rotation values. All the isolated compounds (1-7), except for 2, showed nitric oxide (NO) production inhibitory effect against lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells without cytotoxicity at concentrations up to 30 μg/mL. This is the first report on the yeast-like fungus Cystobasidium laryngis producing phenazines and anti-inflammatory activity of 1-7 including saphenic acid (4).
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