Abstract：
Chronic inflammatory conditions such as obesity, type-2 diabetes, and cardiovascular diseases are the leading causes of mortality worldwide. Hence, much research interest in bioactive peptides has been stimulated due to lack of potent pharmacological interventions. Although many such peptides have been identified from food proteins, insufficient information is available on their structure-function relationship. Presence of hydrophobic and positively charged amino acids is a common occurrence for the peptides with anti-inflammatory properties. However, inconsistent findings have also been reported. Most of the food-derived peptides exhibited their anti-inflammatory activities primarily by inhibiting signaling components of either NF-κB or MAPK pathway, which are the two major pathways involved in chronic inflammation following uncontrolled signal activation. This review highlighted the structural requirements of the peptides to exhibit anti-inflammatory activity based on the current knowledge about food-derived anti-inflammatory peptides and their underlying molecular mechanisms of action. PRACTICAL APPLICATIONS: While research in the food-derived bioactive peptide is gaining momentum, but the ability to translate these new findings into the commercial product such as nutraceuticals and functional foods, remains delayed. The most prominent reasons for this delay are the lack of detailed research on, (i) the structure-function relationship of the peptide and the underlying molecular mechanisms of these bioactive peptides, and (ii) the interaction of these peptides with different cellular elements in the disease pathophysiology. This review gives an insight into the structure-activity relationship of bioactive peptides involved in anti-inflammatory responses. The information provided here would be highly beneficial to describe the possible anti-inflammatory activity of any newly identified peptides from different food sources.
摘要：
慢性炎症，如肥胖，2型糖尿病,和心血管疾病是全球死亡的主要原因。因此，由于缺乏有效的药理干预措施，人们对生物活性肽的研究兴趣得到了激发。尽管已经从食物蛋白中鉴定出许多这样的肽,关于它们的结构-功能关系的信息不足。疏水性和带正电荷的氨基酸的存在对于具有抗炎特性的肽是常见的。然而,也有不一致的发现。大多数食物衍生肽主要通过抑制NF-κB或MAPK途径的信号传导成分来表现其抗炎活性。这是不受控制的信号激活后参与慢性炎症的两条主要途径。这篇综述强调了基于当前有关食物衍生的抗炎肽及其潜在分子作用机制的知识，这些肽具有抗炎活性的结构要求。实际应用：虽然对食品衍生的生物活性肽的研究正在获得动力，但是能够将这些新发现转化为商业产品，如营养食品和功能性食品，仍然延迟。造成这种延误的最突出原因是缺乏详细的研究，（i）肽的结构-功能关系和这些生物活性肽的潜在分子机制，和（ii）这些肽与疾病病理生理学中不同细胞元件的相互作用。本文综述了参与抗炎反应的生物活性肽的构效关系。这里提供的信息对于描述来自不同食物来源的任何新鉴定的肽的可能的抗炎活性将是非常有益的。
