Wnt 通路抑制剂 vantictummab 联合 nab - 紫杉醇和吉西他滨在先前未治疗的转移性胰腺癌患者中的 1b 期剂量递增研究。
关键词: Gemcitabine Metastatic pancreatic adenocarcinoma Nab-paclitaxel Phase 1b Vantictumab
Mesh : Adenocarcinoma / drug therapy metabolism Aged Albumins / therapeutic use Antibodies, Monoclonal / therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cohort Studies Deoxycytidine / analogs & derivatives therapeutic use Female Humans Male Maximum Tolerated Dose Middle Aged Paclitaxel / therapeutic use Pancreatic Neoplasms / drug therapy metabolism Wnt Signaling Pathway / drug effects Gemcitabine Pancreatic Neoplasms
来 源:
DOI:10.1007/s10637-019-00824-1
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