PDF(Sci-hub)
Abstract：
BACKGROUND: Four species of Strongyloides, Strongyloides felis, Strongyloides planiceps, Strongyloides stercoralis and Strongyloides tumefaciens, have been identified in cats based on morphology and location in the host with limited data on the prevalence and disease potential of these different species. Strongyloides tumefaciens adults are located in colonic nodules while the other three species are in the small intestine. The literature on Strongyloides in cats is scattered and has never been compiled. The aim of this article is to provide a short review of the existing literature on Strongyloides spp. in cats, to describe the pathology of colonic nodules containing Strongyloides sp. seen at necropsies of cats in St. Kitts, West Indies, and to provide the first unequivocal report of zoonotic S. stercoralis in cats based on sequencing analysis of a portion of the cytochrome c oxidase subunit 1 (cox1) gene, and supported by phylogenetic analysis.
RESULTS: Colonic nodules containing sections of nematodes, histologically compatible with Strongyloides sp. were seen during necropsy in six cats in St. Kitts, West Indies. Sequencing of the cox1 gene of the mitochondrial DNA extracted from colonic nodules from two of these cats matched sequences of the zoonotic strain of S. stercoralis.
CONCLUSIONS: The morphological similarities between S. stercoralis-associated colonic nodules and previous reports of S. tumefaciens, together with the insufficient defining criteria for S. tumefaciens raises questions about the validity of the species. Further sampling and genetic characterization of isolates is needed to understand the species in cats and their zoonotic potential.
RESULTS: Colonic nodules containing sections of nematodes, histologically compatible with Strongyloides sp. were seen during necropsy in six cats in St. Kitts, West Indies. Sequencing of the cox1 gene of the mitochondrial DNA extracted from colonic nodules from two of these cats matched sequences of the zoonotic strain of S. stercoralis.
CONCLUSIONS: The morphological similarities between S. stercoralis-associated colonic nodules and previous reports of S. tumefaciens, together with the insufficient defining criteria for S. tumefaciens raises questions about the validity of the species. Further sampling and genetic characterization of isolates is needed to understand the species in cats and their zoonotic potential.
摘要：
背景：四种类圆线虫，类圆线虫，圆圆线虫，赤圆圆线虫和根癌圆线虫，已经根据宿主中的形态和位置在猫中进行了鉴定，而关于这些不同物种的患病率和疾病潜力的数据有限。根癌圆线虫成虫位于结肠结节中，而其他三种则位于小肠中。关于猫的类圆线虫的文献是分散的，从未被汇编过。本文的目的是对有关类圆线虫的现有文献进行简短回顾。在猫中，描述含有类圆线虫的结肠结节的病理学。在圣基茨的猫尸检中看到，西印度群岛,并根据部分细胞色素c氧化酶亚基1（cox1）基因的测序分析，提供猫中人畜共患S.stercoralis的第一份明确报告，并得到系统发育分析的支持。
结果：包含线虫切片的结肠结节，在组织学上与类圆线虫相容。在圣基茨的六只猫尸检中看到，西印度群岛.从其中两只猫的结肠结节中提取的线粒体DNA的cox1基因的测序与人畜共患S.stercoralis的序列匹配。
结论：胸骨链球菌相关结肠结节与之前报道的根癌链球菌的形态学相似性，再加上根癌链球菌的定义标准不足，引发了对该物种有效性的质疑。需要对分离株进行进一步的采样和遗传表征，以了解猫的物种及其人畜共患潜力。
结果：包含线虫切片的结肠结节，在组织学上与类圆线虫相容。在圣基茨的六只猫尸检中看到，西印度群岛.从其中两只猫的结肠结节中提取的线粒体DNA的cox1基因的测序与人畜共患S.stercoralis的序列匹配。
结论：胸骨链球菌相关结肠结节与之前报道的根癌链球菌的形态学相似性，再加上根癌链球菌的定义标准不足，引发了对该物种有效性的质疑。需要对分离株进行进一步的采样和遗传表征，以了解猫的物种及其人畜共患潜力。
