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Abstract：
While the emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) and related infections pose serious threats to global public health, the epidemiology and associated risk factors remain poorly understood and vary by geography.
In a case-controlled retrospective study, we examined the prevalence, patient background and risk factors for CRE colonisation and infections, and all patient-derived CRE from January 2015 to January 2017. Isolated carbapenem-susceptible Enterobacteriaceae (CSE) from 2875 enrolled patients were randomly selected during the study.
CRE colonisation and infections detection rates were 47/2875 (1.6%). Respiratory tract specimens were most frequently seen in 20/47 (42.6%) cases. Klebsiella pneumoniae was the main isolate in 35/47 (74.5%) CRE. As for carbapenemase, KPC-2-producing bacteria was most frequently detected in 38/47 (80.9%) Enterobacteriaceae. No underlying conditions (P = 0.004), pulmonary diseases (P = 0.018) and no antibiotics used prior to culture within 30 days (P < 0.001) were statistically significant between the CRE and CSE groups.
Klebsiellapneumoniae was the main isolate of CRE. The blaKPC-2 was the predominant CRE gene. Underlying conditions especially pulmonary diseases and antibiotics used prior to culture within 30 days represented key risk factors for acquisition of CRE.
In a case-controlled retrospective study, we examined the prevalence, patient background and risk factors for CRE colonisation and infections, and all patient-derived CRE from January 2015 to January 2017. Isolated carbapenem-susceptible Enterobacteriaceae (CSE) from 2875 enrolled patients were randomly selected during the study.
CRE colonisation and infections detection rates were 47/2875 (1.6%). Respiratory tract specimens were most frequently seen in 20/47 (42.6%) cases. Klebsiella pneumoniae was the main isolate in 35/47 (74.5%) CRE. As for carbapenemase, KPC-2-producing bacteria was most frequently detected in 38/47 (80.9%) Enterobacteriaceae. No underlying conditions (P = 0.004), pulmonary diseases (P = 0.018) and no antibiotics used prior to culture within 30 days (P < 0.001) were statistically significant between the CRE and CSE groups.
Klebsiellapneumoniae was the main isolate of CRE. The blaKPC-2 was the predominant CRE gene. Underlying conditions especially pulmonary diseases and antibiotics used prior to culture within 30 days represented key risk factors for acquisition of CRE.
摘要：
尽管耐碳青霉烯类肠杆菌（CRE）和相关感染的出现和传播对全球公共卫生构成了严重威胁，流行病学和相关危险因素仍然知之甚少,并且因地域而异.
在一项病例对照回顾性研究中，我们检查了患病率，CRE定植和感染的患者背景和危险因素，以及2015年1月至2017年1月的所有患者来源的CRE。在研究过程中随机选择2875名入选患者的碳青霉烯类敏感肠杆菌（CSE）。
CRE定植和感染检出率为47/2875（1.6％）。呼吸道标本最常见于20/47例（42.6％）。肺炎克雷伯菌是35/47(74.5%)CRE的主要分离株。至于碳青霉烯酶,在38/47（80.9％）肠杆菌科中最常见的是产生KPC-2的细菌。无潜在条件(P=0.004)，肺部疾病(P=0.018)和培养前30天内未使用抗生素(P<0.001)在CRE和CSE组之间有统计学意义.
肺炎克雷伯菌是CRE的主要分离株。blaKPC-2是主要的CRE基因。潜在的疾病，尤其是肺部疾病和30天内培养前使用的抗生素，代表了获得CRE的关键风险因素。
在一项病例对照回顾性研究中，我们检查了患病率，CRE定植和感染的患者背景和危险因素，以及2015年1月至2017年1月的所有患者来源的CRE。在研究过程中随机选择2875名入选患者的碳青霉烯类敏感肠杆菌（CSE）。
CRE定植和感染检出率为47/2875（1.6％）。呼吸道标本最常见于20/47例（42.6％）。肺炎克雷伯菌是35/47(74.5%)CRE的主要分离株。至于碳青霉烯酶,在38/47（80.9％）肠杆菌科中最常见的是产生KPC-2的细菌。无潜在条件(P=0.004)，肺部疾病(P=0.018)和培养前30天内未使用抗生素(P<0.001)在CRE和CSE组之间有统计学意义.
肺炎克雷伯菌是CRE的主要分离株。blaKPC-2是主要的CRE基因。潜在的疾病，尤其是肺部疾病和30天内培养前使用的抗生素，代表了获得CRE的关键风险因素。
