Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum.

• 影响指数: 2.745
• 发表时间: Jun 2019
• 来源期刊: Chem Biodivers
• DOI: 10.1002/cbdv.201900192
• PMID: 31107589
• 文章类型: Journal Article
• 作者列表: Li SG,Huang XJ,Zhong YL,Li MM,Li YL,Wang Y,Ye WC

关键词: Polygonum multiflorum; TSG; anti-inflammatory activity; biological activity; oligomeric stilbene; phytochemistry

Mesh: Animals; Circular Dichroism; Fallopia multiflora / chemistry metabolism; Glycosides / chemistry; Lipopolysaccharides / pharmacology; Macrophages / cytology drug effects metabolism; Mice; Molecular Conformation; Nitric Oxide / metabolism; Oligosaccharides / chemistry isolation & purification pharmacology; Plant Roots / chemistry metabolism; RAW 264.7 Cells; Stilbenes / chemistry

Abstract

Five new trans-2,3,5,4\'-tetrahydroxystilbene 2-O-β-d-glucopyranoside (TSG)-based stilbene glycoside oligomers (1-5) were isolated from the roots of Polygonum multiflorum. Their structures were elucidated by comprehensive spectroscopic analyses and chemical evidences. The absolute configurations of 1, 2, 4, and 5 were established by quantum-chemical electronic circular dichroism (ECD) calculations. Putative biosynthetic pathways of 1-5 were proposed using TSG as the key precursor. In addition, compounds 1 (multiflorumiside H) and 3 (multiflorumiside J) exhibited moderate inhibitory activities against NO production in LPS-stimulated RAW264.7 cells.