%0 Journal Article
%T Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum.
%A Li SG
%A Huang XJ
%A Zhong YL
%A Li MM
%A Li YL
%A Wang Y
%A Ye WC
%J Chem Biodivers
%V 16
%N 6
%D Jun 2019
%M 31107589
%F 2.745
%R 10.1002/cbdv.201900192
%X Five new trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-d-glucopyranoside (TSG)-based stilbene glycoside oligomers (1-5) were isolated from the roots of Polygonum multiflorum. Their structures were elucidated by comprehensive spectroscopic analyses and chemical evidences. The absolute configurations of 1, 2, 4, and 5 were established by quantum-chemical electronic circular dichroism (ECD) calculations. Putative biosynthetic pathways of 1-5 were proposed using TSG as the key precursor. In addition, compounds 1 (multiflorumiside H) and 3 (multiflorumiside J) exhibited moderate inhibitory activities against NO production in LPS-stimulated RAW264.7 cells.