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Abstract：
OBJECTIVE: To investigate the prevalence and location of optic nerve head drusen and their potential association with other PXE-related ophthalmic abnormalities.
METHODS: Thirty-eight of the 155 patients (57 male and 98 female aged 49±17 years) included in this retrospective study had optic nerve head drusen. All of the patients underwent a comprehensive ophthalmic examination, including color images using red-free, blue and red filters, autofluorescence imaging and late-phase ICG frames. Comparative analysis of both groups (optic nerve head drusen or not) was conducted using R statistical software.
RESULTS: The prevalence of optic nerve head drusen in our cohort was 24.5%. In this study, no evidence of a significant link between optic nerve head drusen and other fundus abnormalities was detected. They were more commonly located in the nasal sector than in the temporal sector of the optic disc (P<0.001). They were more frequently situated superonasally than inferonasally (P<0.004), superotemporally (P<0.001) or inferotemporally (P<0.03). No central visual field defect was observed in OND+ patients who were unaffected by macular disorders.
CONCLUSIONS: We hypothesized this predominantly nasal primary location may result from greater sensitivity in the nasal optic nerve fibers which follow a much more angular path once they arrive in the scleral canal, accounting for accumulation of axoplasmic debris.
CONCLUSIONS: In PXE, optic nerve head drusen are mostly located in the superonasal quadrant, causing progressive optic nerve invasion but probably no central visual field defects.
METHODS: Thirty-eight of the 155 patients (57 male and 98 female aged 49±17 years) included in this retrospective study had optic nerve head drusen. All of the patients underwent a comprehensive ophthalmic examination, including color images using red-free, blue and red filters, autofluorescence imaging and late-phase ICG frames. Comparative analysis of both groups (optic nerve head drusen or not) was conducted using R statistical software.
RESULTS: The prevalence of optic nerve head drusen in our cohort was 24.5%. In this study, no evidence of a significant link between optic nerve head drusen and other fundus abnormalities was detected. They were more commonly located in the nasal sector than in the temporal sector of the optic disc (P<0.001). They were more frequently situated superonasally than inferonasally (P<0.004), superotemporally (P<0.001) or inferotemporally (P<0.03). No central visual field defect was observed in OND+ patients who were unaffected by macular disorders.
CONCLUSIONS: We hypothesized this predominantly nasal primary location may result from greater sensitivity in the nasal optic nerve fibers which follow a much more angular path once they arrive in the scleral canal, accounting for accumulation of axoplasmic debris.
CONCLUSIONS: In PXE, optic nerve head drusen are mostly located in the superonasal quadrant, causing progressive optic nerve invasion but probably no central visual field defects.
摘要：
目的：探讨视神经头玻璃疣的患病率和部位及其与其他PXE相关眼科异常的潜在关联。
方法：本回顾性研究的155例患者中有38例（男57例，女98例，年龄49±17岁）患有视神经头玻璃疣。所有患者都接受了全面的眼科检查，包括使用无红色的彩色图像，蓝色和红色过滤器，自发荧光成像和晚期ICG帧。使用R统计软件对两组（视神经乳头玻璃疣与否）进行比较分析。
结果：我们队列中视神经头玻璃疣的患病率为24.5%。在这项研究中,没有发现视神经头玻璃疣与其他眼底异常之间存在显着联系的证据。它们更常见于鼻部，而不是视盘的颞部（P<0.001）。他们更频繁地位于鼻上比鼻下（P<0.004），超颞侧（P<0.001）或下颞侧（P<0.03）。未受黄斑病变影响的OND+患者未观察到中央视野缺损。
结论：我们假设这种主要的鼻部原发性位置可能是由于鼻视神经纤维的敏感性更高，一旦它们到达巩膜管后，鼻视神经纤维的角度更大，考虑轴浆碎片的积累。
结论：在PXE中，视神经头玻璃疣大多位于鼻上象限，导致进行性视神经侵犯，但可能没有中央视野缺损。
方法：本回顾性研究的155例患者中有38例（男57例，女98例，年龄49±17岁）患有视神经头玻璃疣。所有患者都接受了全面的眼科检查，包括使用无红色的彩色图像，蓝色和红色过滤器，自发荧光成像和晚期ICG帧。使用R统计软件对两组（视神经乳头玻璃疣与否）进行比较分析。
结果：我们队列中视神经头玻璃疣的患病率为24.5%。在这项研究中,没有发现视神经头玻璃疣与其他眼底异常之间存在显着联系的证据。它们更常见于鼻部，而不是视盘的颞部（P<0.001）。他们更频繁地位于鼻上比鼻下（P<0.004），超颞侧（P<0.001）或下颞侧（P<0.03）。未受黄斑病变影响的OND+患者未观察到中央视野缺损。
结论：我们假设这种主要的鼻部原发性位置可能是由于鼻视神经纤维的敏感性更高，一旦它们到达巩膜管后，鼻视神经纤维的角度更大，考虑轴浆碎片的积累。
结论：在PXE中，视神经头玻璃疣大多位于鼻上象限，导致进行性视神经侵犯，但可能没有中央视野缺损。
