PDF(Sci-hub)
Abstract：
OBJECTIVE: In rare cases, patients with epilepsy of infancy withmigrating focal seizures (EIMFS) exhibit suppression-burst (SB) patterns on electroencephalography (EEG), similar to the findings observed in patients with Ohtahara syndrome and early myoclonic encephalopathy. In this report, we discuss six cases of EIMFS in which patients exhibited two types of SB patterns.
METHODS: We evaluated six patients with EIMFS who had been admitted to the NHO Shizuoka Institute of Epilepsy and Neurological Disorders between 2011 and 2018. We retrospectively examined clinical characteristics and EEG findings for each patient. In all patients, the first EEG was performed within 1 month after seizure onset. Afterwards, EEG examinations were performed at irregular intervals (ranging from 1 to 5 months).
RESULTS: Age at seizure onset ranged from 2 days to 3 months. SB was first detected within 1 month of age in two patients, and within the range of 3-14 months in the remaining four patients. Among the latter four patients, SB patterns persisted at the final EEG recording in three patients (34-54 months). In all patients, SB patterns were observed during sleep only. Interhemispheric asynchrony in SB was observed in the two patients who exhibited SB within 1 month of age, while synchronous SB patterns were observed in the remaining four patients.
CONCLUSIONS: Our findings indicate that EIMFS may be associated with two types of SB patterns (early-onset and late-onset), which can be distinguished based on the stage of emergence and level of synchrony.
METHODS: We evaluated six patients with EIMFS who had been admitted to the NHO Shizuoka Institute of Epilepsy and Neurological Disorders between 2011 and 2018. We retrospectively examined clinical characteristics and EEG findings for each patient. In all patients, the first EEG was performed within 1 month after seizure onset. Afterwards, EEG examinations were performed at irregular intervals (ranging from 1 to 5 months).
RESULTS: Age at seizure onset ranged from 2 days to 3 months. SB was first detected within 1 month of age in two patients, and within the range of 3-14 months in the remaining four patients. Among the latter four patients, SB patterns persisted at the final EEG recording in three patients (34-54 months). In all patients, SB patterns were observed during sleep only. Interhemispheric asynchrony in SB was observed in the two patients who exhibited SB within 1 month of age, while synchronous SB patterns were observed in the remaining four patients.
CONCLUSIONS: Our findings indicate that EIMFS may be associated with two types of SB patterns (early-onset and late-onset), which can be distinguished based on the stage of emergence and level of synchrony.
摘要：
目标：在极少数情况下，婴儿期癫痫伴迁移局灶性癫痫发作（EIMFS）的患者在脑电图（EEG）上表现出抑制爆发（SB）模式，与Ohtahara综合征和早期肌阵挛性脑病患者的发现相似。在这份报告中,我们讨论了6例EIMFS，其中患者表现出两种SB模式。
方法：我们评估了2011年至2018年NHO静冈癫痫和神经系统疾病研究所收治的6例EIMFS患者。我们回顾性检查了每位患者的临床特征和脑电图结果。在所有患者中，首次脑电图在癫痫发作后1个月内进行.之后,以不规则的间隔（1至5个月）进行EEG检查。
结果：癫痫发作年龄为2天至3个月。两名患者在1月龄内首次检测到SB，其余4名患者在3-14个月的范围内。在后四名患者中，SB模式在三名患者（34-54个月）的最终EEG记录中持续存在。在所有患者中，仅在睡眠期间观察到SB模式。在1月龄内表现出SB的两名患者中观察到SB的半球间异步，而在其余4例患者中观察到同步SB模式。
结论：我们的发现表明EIMFS可能与两种类型的SB模式（早发性和晚发性）有关，这可以根据出现的阶段和同步水平来区分。
方法：我们评估了2011年至2018年NHO静冈癫痫和神经系统疾病研究所收治的6例EIMFS患者。我们回顾性检查了每位患者的临床特征和脑电图结果。在所有患者中，首次脑电图在癫痫发作后1个月内进行.之后,以不规则的间隔（1至5个月）进行EEG检查。
结果：癫痫发作年龄为2天至3个月。两名患者在1月龄内首次检测到SB，其余4名患者在3-14个月的范围内。在后四名患者中，SB模式在三名患者（34-54个月）的最终EEG记录中持续存在。在所有患者中，仅在睡眠期间观察到SB模式。在1月龄内表现出SB的两名患者中观察到SB的半球间异步，而在其余4例患者中观察到同步SB模式。
结论：我们的发现表明EIMFS可能与两种类型的SB模式（早发性和晚发性）有关，这可以根据出现的阶段和同步水平来区分。
