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Abstract：
OBJECTIVE: The aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas.
METHODS: Immunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.
RESULTS: Expression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%), and SCC (100%). In the totality of tumors, loss of FHIT expression was found in 46.7% (106/227) and was significantly associated with advanced T stage and UICC stage, high-grade histology, loss of p27, PI3K, and survivin. FHIT positivity went along with significantly better overall and disease-specific survival. Negativity of p27 occurred in 28.7% (70/244) of tumors, particularly in SDC (54.4%) and SCC (50%). In the totality of tumors, p27 was associated with advanced patient age, high-grade histology, PI3K, survivin as well as better overall and disease-specific survival (p < 0.05). Positive pERK1/ERK2 expression correlated with positive survivin expression but did not affect overall survival in the totality of tumors. In mucoepidermoid carcinomas, pERK1/ERK2 expression was associated with low-grade malignancy, positive nuclear survivin, and better disease-specific survival.
CONCLUSIONS: Loss of FHIT and p27 characterizes aggressive tumor growth and unfavorable prognosis in salivary gland cancer.
CONCLUSIONS: The results may help to stratify patient-specific therapies according to individual tumor characteristics.
METHODS: Immunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.
RESULTS: Expression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%), and SCC (100%). In the totality of tumors, loss of FHIT expression was found in 46.7% (106/227) and was significantly associated with advanced T stage and UICC stage, high-grade histology, loss of p27, PI3K, and survivin. FHIT positivity went along with significantly better overall and disease-specific survival. Negativity of p27 occurred in 28.7% (70/244) of tumors, particularly in SDC (54.4%) and SCC (50%). In the totality of tumors, p27 was associated with advanced patient age, high-grade histology, PI3K, survivin as well as better overall and disease-specific survival (p < 0.05). Positive pERK1/ERK2 expression correlated with positive survivin expression but did not affect overall survival in the totality of tumors. In mucoepidermoid carcinomas, pERK1/ERK2 expression was associated with low-grade malignancy, positive nuclear survivin, and better disease-specific survival.
CONCLUSIONS: Loss of FHIT and p27 characterizes aggressive tumor growth and unfavorable prognosis in salivary gland cancer.
CONCLUSIONS: The results may help to stratify patient-specific therapies according to individual tumor characteristics.
摘要：
目的：本研究的目的是研究生物标志物FHIT的预测价值，p27和pERK1/ERK2在唾液腺癌中的作用。
方法：FHIT的免疫组织化学染色，对265例涎腺癌患者进行p27和pERK1/ERK2，以及与临床组织病理学数据的关联，总生存率,并检查了疾病特异性生存率。
结果：FHIT的表达（快速评分98.7与206.4）和p27（QS187.3与244.8）与非肿瘤对照组织相比，在癌中显着更低。ACC经常发生FHIT损失(55.2%)，SDC（68.2%），SCC（100%）。在整个肿瘤中，在46.7％（106/227）中发现FHIT表达丧失，并且与晚期T期和UICC期显著相关，高级组织学，P27、PI3K、和幸存者。FHIT阳性伴随着显著更好的总体和疾病特异性生存率。p27阴性发生在28.7%(70/244)的肿瘤中,特别是在SDC(54.4%)和SCC(50%)中。在整个肿瘤中，p27与患者高龄相关，高级组织学，PI3K,survivin以及更好的总体和疾病特异性生存率（p<0.05）。pERK1/ERK2阳性表达与survivin阳性表达相关，但不影响整个肿瘤的总体生存率。在粘液表皮样癌中，pERK1/ERK2表达与低度恶性肿瘤相关，积极的核幸存者，和更好的疾病特异性生存。
结论：在涎腺癌中，FHIT和p27的丢失表征了肿瘤的侵袭性生长和不良预后。
结论：结果可能有助于根据个体肿瘤特征对患者特异性治疗进行分层。
方法：FHIT的免疫组织化学染色，对265例涎腺癌患者进行p27和pERK1/ERK2，以及与临床组织病理学数据的关联，总生存率,并检查了疾病特异性生存率。
结果：FHIT的表达（快速评分98.7与206.4）和p27（QS187.3与244.8）与非肿瘤对照组织相比，在癌中显着更低。ACC经常发生FHIT损失(55.2%)，SDC（68.2%），SCC（100%）。在整个肿瘤中，在46.7％（106/227）中发现FHIT表达丧失，并且与晚期T期和UICC期显著相关，高级组织学，P27、PI3K、和幸存者。FHIT阳性伴随着显著更好的总体和疾病特异性生存率。p27阴性发生在28.7%(70/244)的肿瘤中,特别是在SDC(54.4%)和SCC(50%)中。在整个肿瘤中，p27与患者高龄相关，高级组织学，PI3K,survivin以及更好的总体和疾病特异性生存率（p<0.05）。pERK1/ERK2阳性表达与survivin阳性表达相关，但不影响整个肿瘤的总体生存率。在粘液表皮样癌中，pERK1/ERK2表达与低度恶性肿瘤相关，积极的核幸存者，和更好的疾病特异性生存。
结论：在涎腺癌中，FHIT和p27的丢失表征了肿瘤的侵袭性生长和不良预后。
结论：结果可能有助于根据个体肿瘤特征对患者特异性治疗进行分层。
