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Abstract：
Brain swelling is one of the most robust predictors of outcome following brain injury, including ischemic, traumatic, hemorrhagic, metabolic or other injury. Depending on the specific type of insult, brain swelling can arise from the combined space-occupying effects of extravasated blood, extracellular edema fluid, cellular swelling, vascular engorgement and hydrocephalus. Of these, arguably the least well appreciated is cellular swelling. Here, we explore current knowledge regarding swelling of astrocytes, the most abundant cell type in the brain, and the one most likely to contribute to pathological brain swelling. We review the major molecular mechanisms identified to date that contribute to or mitigate astrocyte swelling via ion transport, and we touch upon the implications of astrocyte swelling in health and disease.
摘要：
脑肿胀是脑损伤后最有力的预后预测因子之一，包括缺血,创伤性,出血性,代谢或其他伤害。根据侮辱的具体类型，脑肿胀可能是由于血液外渗的综合占据空间效应引起的，细胞外水肿液，细胞肿胀，血管充血和脑积水。其中,可以说，最不受欢迎的是细胞肿胀。这里,我们探索目前有关星形胶质细胞肿胀的知识，大脑中最丰富的细胞类型，也是最有可能导致病理性脑肿胀的人。我们回顾了迄今为止确定的通过离子转运促进或减轻星形胶质细胞肿胀的主要分子机制，我们探讨了星形胶质细胞肿胀对健康和疾病的影响。
