Abstract：
Wound healing in diabetes is frequently impaired and its treatment remains a challenge. The ability of topical application of cerium (Ce) dioxide nanoparticles (CNPs) to accelerate wound healing in an animal model provides a rationale to develop this technology for use in humans affected by traumatic injury, diabetes and burns. We first described a case report of successful topical treatment of neuropathic diabetic foot ulcers with novel gel containing CNPs. The CNPs has bacteriostatic activity, anti-inflammatory properties and can penetrated into the wound tissue and reduced oxidative damage therefore protect regenerative tissue, suggesting a therapeutic potential for topical treatment of diabetic foot ulcers.
摘要：
糖尿病的伤口愈合经常受损，其治疗仍然是一个挑战。在动物模型中局部应用二氧化铈（Ce）纳米颗粒（CNPs）加速伤口愈合的能力为开发该技术用于受外伤影响的人类提供了理论基础。糖尿病和烧伤。我们首先描述了使用含有CNP的新型凝胶成功局部治疗神经性糖尿病足溃疡的病例报告。CNPs具有抑菌活性，抗炎特性，可以渗透到伤口组织和减少氧化损伤，因此保护再生组织，提示局部治疗糖尿病足溃疡的治疗潜力。
