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Abstract：
Cognitive dysfunction syndrome (CDS) is a common condition in senior dogs, which may be analogous to dementia such as Alzheimer\'s disease (AD) in people. In humans, AD has been associated with many risk factors such as reduced cerebral glucose metabolism, docosahexaenoic acid (DHA) deficiency, chronic oxidative stress, and chronic inflammation. By targeting some of these risk factors, we have developed two nutritional solutions (medium chain triglyceride, MCT and Brain Protection Blend, BPB) to enhance cognitive function and slow aging-induced cognitive decline. These have been positively evaluated in colony housed senior dogs and cats. The objective of this clinical study was to evaluate the effects of diets with MCTs and the BPB on client-owned dogs with CDS. Participating veterinary clinics screened senior dogs for signs of CDS as determined by a Senior Canine Behavior Questionnaire and a Canine Medical Health Questionnaire. Eighty-seven dogs were randomly enrolled into one of three diet groups with 29 dogs per group: Control, 6.5% MCT oil + BPB (6.5% MCT diet), 9% MCT oil + BPB (9% MCT diet). Diets were fed for a period of 90 days, and each dog\'s CDS signs were re-evaluated at day 30 and day 90. All 6 categories of the CDS signs were significantly improved (p <0.05) in the dogs given the 6.5% MCT diet at the end of the 90-day study. Control only improved in 4 out 6 categories. The 9% MCT diet only improved in dogs that accepted the diet. The results from this dog study confirm the benefits of MCT and BPB in managing clinical signs of CDS in dogs. The results support our hypothesis that targeting known risk factors associated with brain aging and AD is able to improve symptoms of CDS in dogs. These data may facilitate the development of similar nutrient blends to manage MCI and AD.
摘要：
认知功能障碍综合征（CDS）是老年犬的常见病，这可能类似于痴呆症，如阿尔茨海默病（AD）。在人类中,AD与许多危险因素有关，例如脑葡萄糖代谢降低，二十二碳六烯酸（DHA）缺乏症，慢性氧化应激，慢性炎症。通过针对这些风险因素中的一些，我们开发了两种营养解决方案（中链甘油三酯，MCT和脑保护的混合，BPB）以增强认知功能并减缓衰老引起的认知下降。这些在饲养高级狗和猫的殖民地中得到了积极评价。该临床研究的目的是评估具有MCT和BPB的饮食对具有CDS的客户拥有的狗的影响。参与的兽医诊所根据高级犬行为问卷和犬医疗健康问卷确定，对高级犬进行了CDS迹象筛查。将87只狗随机纳入三个饮食组之一，每组29只狗：对照组，6.5%MCT油+BPB（6.5%MCT饮食），9%MCT油+BPB(9%MCT日粮)。饮食喂养90天，在第30天和第90天重新评估每只狗的CDS征象。在90天研究结束时给予6.5%MCT饮食的狗中,所有6类CDS体征均显著改善(p<0.05)。控制仅在6个类别中的4个类别中有所改善。9%MCT饮食仅在接受该饮食的狗中得到改善。这项狗研究的结果证实了MCT和BPB在管理狗的CDS临床症状方面的益处。结果支持我们的假设，即针对与大脑衰老和AD相关的已知风险因素能够改善狗的CDS症状。这些数据可能有助于开发类似的营养混合物来管理MCI和AD。
