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Abstract：
The cerebellum is involved in the control of movement, emotional responses, and reward processing. The tree shrew is the closest living relative of primates. However, little is known not only about the systematic nomenclature for the tree shrew cerebellum but also about the detailed neurochemical characterization and afferent projections. In this study, Nissl staining and acetylcholinesterase histochemistry were used to reveal anatomical features of the cerebellum of tree shrews (Tupaia belangeri chinensis). The cerebellar cortex presented a laminar structure. The morphological characteristics of the cerebellum were comprehensively described in the coronal, sagittal, and horizontal sections. Moreover, distributive maps of calbindin-immunoreactive (-ir) cells in the Purkinje cell layer of the cerebellum of tree shrews were depicted using coronal, sagittal, and horizontal schematics. In addition, 5th cerebellar lobule (5Cb)-projecting neurons were present in the pontine nuclei, reticular nucleus, spinal vestibular nucleus, ventral spinocerebellar tract, and inferior olive of the tree shrew brain. The anterior part of the paramedian lobule of the cerebellum (PMa) received mainly strong innervation from the lateral reticular nucleus, inferior olive, pontine reticular nucleus, spinal trigeminal nucleus, pontine nuclei, and reticulotegmental nucleus of the pons. The present results provide the first systematic nomenclature, detailed atlas of the whole cerebellum, and whole-brain mapping of afferent projections to the 5Cb and PMa in tree shrews. Our findings provide morphological support for tree shrews as an alternative model for studies of human cerebellar pathologies.
摘要：
小脑参与运动的控制，情绪反应,和奖励处理。树the是灵长类动物的近亲。然而,鲜为人知的不仅是系统命名的树的小脑，但也详细的神经化学表征和传入投影。在这项研究中,Nissl染色和乙酰胆碱酯酶组织化学用于揭示树sh（Tupaiabelangerichinensis）小脑的解剖特征。小脑皮层呈现层状结构。小脑的形态特征在冠状区进行了全面的描述，矢状,和水平部分。此外，使用冠状图描绘了树the小脑Purkinje细胞层中钙结合蛋白免疫反应性（-ir）细胞的分布图，矢状,和水平示意图。此外,脑桥核中存在第5小脑小叶（5Cb）投射神经元，网状核,前庭脊髓核,腹侧脊髓小脑束，和树的大脑的下橄榄。小脑旁正中小叶（PMa）的前部主要接受来自外侧网状核的强烈神经支配，劣等橄榄，脑桥网状核,三叉神经脊髓核,脑桥核,和脑桥的网状骨核。目前的结果提供了第一个系统的命名法，整个小脑的详细图集,和全脑映射传入投射到树sh中的5Cb和PMa。我们的发现为树the提供了形态学支持，作为研究人类小脑病理学的替代模型。
