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Abstract：
Bacteria resistant to different classes of antimicrobial agents are a major threat to humanity and risk leading the world towards the return of the pre-antimicrobial era. This study was undertaken to detect the incidence of extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacteria in a tertiary-care hospital in Bhubaneswar, Odisha, India.
Positive bacterial cultures from different clinical samples were identified using a VITEK®2 compact system and the antimicrobial susceptibility profile of different Gram-negative bacteria was analysed.
A total of 2489 clinical samples were collected and processed for culture during the period January 2013 to April 2017. Of 1103 pure bacterial cultures, 690 (62.6%) were Gram-negative bacteria. The antimicrobial susceptibility profile of Gram-negative bacterial strains revealed that 41.3% (n=285) were XDR and 8.1% (n=56) were PDR. Rates of colistin and tigecycline resistance were 16% and 51.9%, respectively.
This situation demands regular surveillance of antimicrobial resistance of Gram-negative bacteria and implementation of an efficient infection control programme.
Positive bacterial cultures from different clinical samples were identified using a VITEK®2 compact system and the antimicrobial susceptibility profile of different Gram-negative bacteria was analysed.
A total of 2489 clinical samples were collected and processed for culture during the period January 2013 to April 2017. Of 1103 pure bacterial cultures, 690 (62.6%) were Gram-negative bacteria. The antimicrobial susceptibility profile of Gram-negative bacterial strains revealed that 41.3% (n=285) were XDR and 8.1% (n=56) were PDR. Rates of colistin and tigecycline resistance were 16% and 51.9%, respectively.
This situation demands regular surveillance of antimicrobial resistance of Gram-negative bacteria and implementation of an efficient infection control programme.
摘要：
对不同类别的抗微生物剂具有抗性的细菌是对人类的主要威胁,并且有可能引领世界回归抗微生物前时代。这项研究旨在检测布巴内斯瓦尔三级医院中广泛耐药（XDR）和耐药（PDR）细菌的发生率，奥里萨邦,印度。
使用VITEK®2紧凑型系统鉴定来自不同临床样品的阳性细菌培养物,并分析不同革兰氏阴性菌的抗微生物敏感性曲线。
在2013年1月至2017年4月期间，共收集并处理了2489个临床样品进行培养。在1103种纯细菌培养物中，690例(62.6%)为革兰氏阴性菌。革兰氏阴性菌菌株的抗菌敏感性曲线显示，XDR占41.3％（n=285），PDR占8.1％（n=56）。粘菌素和替加环素耐药率分别为16%和51.9%,分别。
这种情况需要定期监测革兰氏阴性菌的抗菌素耐药性，并实施有效的感染控制计划。
使用VITEK®2紧凑型系统鉴定来自不同临床样品的阳性细菌培养物,并分析不同革兰氏阴性菌的抗微生物敏感性曲线。
在2013年1月至2017年4月期间，共收集并处理了2489个临床样品进行培养。在1103种纯细菌培养物中，690例(62.6%)为革兰氏阴性菌。革兰氏阴性菌菌株的抗菌敏感性曲线显示，XDR占41.3％（n=285），PDR占8.1％（n=56）。粘菌素和替加环素耐药率分别为16%和51.9%,分别。
这种情况需要定期监测革兰氏阴性菌的抗菌素耐药性，并实施有效的感染控制计划。
