PDF(Pubmed)
Abstract：
One of the key features of macroautophagy/autophagy is the dynamic nature of the membrane rearrangements that take place during expansion of the phagophore, the sequestering compartment that matures into an autophagosome. There are various ways to depict this process, but in most cases the method ultimately relies on a two-dimensional medium. Most people working in the field of autophagy realize that the typical \'C\'-shaped drawing of a phagophore is meant to represent a cup- or bowl-like structure that exists in the cell in 3 dimensions. However, explaining this concept to a lay person often leads to confusion and misinterpretation. Accordingly, we decided to generate a four-dimensional version of the expanding phagophore as a wood sculpture, that depicts this transient compartment in 3 dimensions over time.
ER: endoplasmic reticulum.
ER: endoplasmic reticulum.
摘要：
巨自噬/自噬的关键特征之一是在吞噬团扩张期间发生的膜重排的动态性质，成熟为自噬体的隔离室。有各种各样的方法来描述这个过程，但在大多数情况下，该方法最终依赖于二维介质。在自噬领域工作的大多数人都意识到，典型的“C”形的吞噬体图旨在代表3维细胞中存在的杯状或碗状结构。然而,向外行人解释这个概念往往会导致混乱和误解。因此，我们决定制作一个四维版本的扩展吞噬体作为木雕，这描绘了这个短暂的隔室在3个维度随着时间的推移。
ER:内质网。
ER:内质网。
