Abstract：
Papua New Guinea (PNG) has an emerging tuberculosis (TB) epidemic which has become a national public health priority. In Western Province, there are few data about TB outside Daru and the South Fly District. This study describes the epidemiology of TB diagnosed at Balimo District Hospital (BDH) in the Middle Fly District of Western Province, PNG.
All patients (n = 1614) diagnosed with TB at BDH from April 2013 to February 2017 were recorded. Incidence of reported new cases was calculated for the combined Balimo Urban and Gogodala Rural local level government areas. Analyses investigated patient demographic and clinical information, differences between pulmonary and extrapulmonary TB patients, and predictors of treatment failure.
The average case notification rate (2014-2016) was 727 TB cases per 100 000 people per year. One-quarter of TB cases were in children, and 77.1% of all cases had an extrapulmonary TB diagnosis. There was a 1:1.1 ratio of female to male TB cases. When comparing pulmonary and extrapulmonary TB patients, extrapulmonary TB was more likely in those aged up to 14 years and over 54 years. Extrapulmonary TB was more likely in new patients, and pulmonary TB more likely in previously treated patients. Residence in rural regions was associated with treatment failure.
There is a high burden of TB in the Balimo region, including a very high proportion of extrapulmonary TB. These factors emphasise the importance of BDH as the primary hospital for TB cases in the Balimo region and the Middle Fly District, and the need for resources and staff to manage both drug-susceptible and drug-resistant TB cases.
All patients (n = 1614) diagnosed with TB at BDH from April 2013 to February 2017 were recorded. Incidence of reported new cases was calculated for the combined Balimo Urban and Gogodala Rural local level government areas. Analyses investigated patient demographic and clinical information, differences between pulmonary and extrapulmonary TB patients, and predictors of treatment failure.
The average case notification rate (2014-2016) was 727 TB cases per 100 000 people per year. One-quarter of TB cases were in children, and 77.1% of all cases had an extrapulmonary TB diagnosis. There was a 1:1.1 ratio of female to male TB cases. When comparing pulmonary and extrapulmonary TB patients, extrapulmonary TB was more likely in those aged up to 14 years and over 54 years. Extrapulmonary TB was more likely in new patients, and pulmonary TB more likely in previously treated patients. Residence in rural regions was associated with treatment failure.
There is a high burden of TB in the Balimo region, including a very high proportion of extrapulmonary TB. These factors emphasise the importance of BDH as the primary hospital for TB cases in the Balimo region and the Middle Fly District, and the need for resources and staff to manage both drug-susceptible and drug-resistant TB cases.
摘要：
巴布亚新几内亚（PNG）正在出现结核病（TB）流行，已成为国家公共卫生重点。在西部省,在达鲁和南蝇区以外，关于结核病的数据很少。这项研究描述了在西部省中蝇区的Balimo区医院（BDH）诊断出的结核病的流行病学，PNG。
记录2013年4月至2017年2月在BDH诊断为TB的所有患者（n=1614）。计算了Balimo城市和Gogodala农村地方政府合并地区的报告新病例的发生率。分析调查了患者的人口统计学和临床信息，肺结核病人和肺外结核病人之间的差异，以及治疗失败的预测因素。
平均病例通报率（2014-2016年）为每年每10万人727例TB病例。四分之一的结核病病例是儿童，所有病例中有77.1%诊断为肺外结核.女性与男性结核病病例的比例为1：1.1。当比较肺结核病患者和肺外结核病患者时，肺外结核在年龄在14岁和54岁以上的人群中的可能性更大.肺外结核在新患者中的可能性更大，在以前接受过治疗的患者中，肺结核的可能性更高。居住在农村地区与治疗失败有关。
巴里莫地区的结核病负担很高，包括很高比例的肺外结核。这些因素强调了BDH作为巴利莫地区和中蝇区结核病病例的基层医院的重要性，以及需要资源和人员来管理药物敏感和耐药结核病病例。
记录2013年4月至2017年2月在BDH诊断为TB的所有患者（n=1614）。计算了Balimo城市和Gogodala农村地方政府合并地区的报告新病例的发生率。分析调查了患者的人口统计学和临床信息，肺结核病人和肺外结核病人之间的差异，以及治疗失败的预测因素。
平均病例通报率（2014-2016年）为每年每10万人727例TB病例。四分之一的结核病病例是儿童，所有病例中有77.1%诊断为肺外结核.女性与男性结核病病例的比例为1：1.1。当比较肺结核病患者和肺外结核病患者时，肺外结核在年龄在14岁和54岁以上的人群中的可能性更大.肺外结核在新患者中的可能性更大，在以前接受过治疗的患者中，肺结核的可能性更高。居住在农村地区与治疗失败有关。
巴里莫地区的结核病负担很高，包括很高比例的肺外结核。这些因素强调了BDH作为巴利莫地区和中蝇区结核病病例的基层医院的重要性，以及需要资源和人员来管理药物敏感和耐药结核病病例。
