Abstract：
Glycosylation is an enzymatic process in which a carbohydrate is attached to a functional group from another molecule. Glycosylation is a crucial post translational process in protein modification. The tumor microenvironment produces altered glycans that contribute to cancer progression and aggressiveness. Abnormal glycosylation is widely observed in tumor angiogenesis. Despite many attempts to decipher the role of glycosylation in different aspects of cancer, little is known regarding the roles of glycans in angiogenesis. The blood vessels in tumors are often used to transport oxygen and nutrients for tumor progression and metastasis. The crosstalk within the tumor microenvironment can induce angiogenesis by manipulating these glycans to hijack the normal angiogenesis process, thus promoting tumor growth. Abnormal glycosylation has been shown to promote tumor angiogenesis by degrading the extracellular matrix to activate the angiogenic signaling pathways. This review highlights the latest update on how glycosylation can contribute to tumor angiogenesis that may affect treatment outcomes.
摘要：
糖基化是酶促过程,其中碳水化合物连接到来自另一分子的官能团。糖基化是蛋白质修饰中至关重要的翻译后过程。肿瘤微环境产生导致癌症进展和侵袭性的改变的聚糖。在肿瘤血管生成中广泛观察到异常糖基化。尽管许多人试图破译糖基化在癌症不同方面的作用，关于聚糖在血管生成中的作用知之甚少。肿瘤中的血管通常用于运输氧气和营养物质以用于肿瘤进展和转移。肿瘤微环境内的串扰可以通过操纵这些聚糖劫持正常的血管生成过程来诱导血管生成，从而促进肿瘤生长。已显示异常糖基化通过降解细胞外基质以激活血管生成信号通路来促进肿瘤血管生成。这篇综述强调了糖基化如何促进可能影响治疗结果的肿瘤血管生成的最新更新。
