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Abstract：
BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators\' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators\' polymorphisms can predict the training response to specific training stimuli.
METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words.
RESULTS: All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO₂peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO₂peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/Gly, PPARD rs1053049 TT, PPARD rs2267668 AA and PPARG rs1801282 Ala carriers.
CONCLUSIONS: The human response for aerobic training is significantly influenced by PPARs\' gene polymorphism and their coactivators, where aerobic training can negatively influence glucose metabolism and VO₂peak in some genetically-predisposed individuals.
METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words.
RESULTS: All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO₂peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO₂peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/Gly, PPARD rs1053049 TT, PPARD rs2267668 AA and PPARG rs1801282 Ala carriers.
CONCLUSIONS: The human response for aerobic training is significantly influenced by PPARs\' gene polymorphism and their coactivators, where aerobic training can negatively influence glucose metabolism and VO₂peak in some genetically-predisposed individuals.
摘要：
背景：过氧化物酶体增殖物激活受体（PPARA，PPARG,PPARD)及其转录共激活因子(PPARGC1A，PPARGC1B）基因多态性与肌肉形态，氧气吸收，功率输出和耐久性能。本综述的目的是确定PPARs和/或其共激活剂的多态性是否可以预测对特定训练刺激的训练反应。
方法：根据系统评价和荟萃分析的首选报告项目，针对PPARs和体力活动关键词进行了文献综述.
结果：纳入的所有10项研究均使用有氧训练进行，21至75岁的久坐或老年人群。有氧训练的无应答者(VO2峰值增加，缓慢的肌纤维增加和低密度脂蛋白减少）是PPARGC1Ars8192678Ser/Ser的携带者。有氧训练的负反应者（VO2峰值降低）是PPARDrs2267668G等位基因的携带者。有氧训练的负反应者(降低的葡萄糖耐量和胰岛素反应)是具有PPARGrs1801282Pro/Pro基因型的受试者。有氧训练的最佳反应者是PPARGC1Ars8192678Gly/Gly，PPARDrs1053049TT,PPARDrs2267668AA和PPARGrs1801282Ala运营商。
结论：人对有氧训练的反应受PPARs基因多态性及其共激活剂的显著影响，有氧训练会对一些遗传倾向个体的葡萄糖代谢和VO2峰值产生负面影响。
方法：根据系统评价和荟萃分析的首选报告项目，针对PPARs和体力活动关键词进行了文献综述.
结果：纳入的所有10项研究均使用有氧训练进行，21至75岁的久坐或老年人群。有氧训练的无应答者(VO2峰值增加，缓慢的肌纤维增加和低密度脂蛋白减少）是PPARGC1Ars8192678Ser/Ser的携带者。有氧训练的负反应者（VO2峰值降低）是PPARDrs2267668G等位基因的携带者。有氧训练的负反应者(降低的葡萄糖耐量和胰岛素反应)是具有PPARGrs1801282Pro/Pro基因型的受试者。有氧训练的最佳反应者是PPARGC1Ars8192678Gly/Gly，PPARDrs1053049TT,PPARDrs2267668AA和PPARGrs1801282Ala运营商。
结论：人对有氧训练的反应受PPARs基因多态性及其共激活剂的显著影响，有氧训练会对一些遗传倾向个体的葡萄糖代谢和VO2峰值产生负面影响。
