PDF(Pubmed)
Abstract：
The associations between enteric pathogenic parasites and growth in infants in São Tomé were explored using a refined anthropometric approach to recognize early growth faltering. A birth cohort study was conducted with follow-up to 24 months of age. Microscopic examination for protozoa and soil-transmitted helminths was performed. Anthropometric assessments included: z-scores for weight-for-length (WLZ), length-for-age (LAZ), weight (WAVZ) and length velocities (LAVZ), length-for-age difference (LAD), and wasting and stunting risk (≤-1 SD). Generalized additive mixed effects regression models were used to explore the associations between anthropometric parameters and enteric parasitic infections and cofactors. A total of 475 infants were enrolled, and 282 completed the study. The great majority of infants were asymptomatic. Giardia lamblia was detected in 35.1% of infants in at least one stool sample, helminths in 30.4%, and Cryptosporidium spp. in 14.7%. Giardia lamblia and helminth infections were significantly associated with mean decreases of 0.10 in LAZ and 0.32 in LAD, and of 0.16 in LAZ and 0.48 in LAD, respectively. Cryptosporidium spp. infection was significantly associated with a mean decrease of 0.43 in WAVZ and 0.55 in LAVZ. The underestimated association between subclinical parasitic enteric infections and mild growth faltering in infants should be addressed in public health policies.
摘要：
使用精细的人体测量学方法探索了圣多美地区肠道致病性寄生虫与婴儿生长之间的关联，以识别早期生长步履蹒跚。进行了一项出生队列研究，随访至24个月。对原生动物和土壤传播的蠕虫进行了显微镜检查。人体测量评估包括：长度体重（WLZ）的z分数，年龄长度（LAZ），重量(WAVZ)和长度速度(LAVZ)，年龄长短差(LAD)，以及消瘦和发育迟缓的风险（≤-1SD）。使用广义加性混合效应回归模型来探索人体测量参数与肠道寄生虫感染和辅因子之间的关联。共纳入475名婴儿,282人完成了这项研究。绝大多数婴儿无症状。在至少一个粪便样本中，在35.1％的婴儿中检测到贾第鞭毛虫。蠕虫占30.4%，和隐孢子虫。在14.7%。蓝氏贾第鞭毛虫和蠕虫感染与LAZ和LAD的平均下降0.10和0.32显著相关，LAZ为0.16，LAD为0.48，分别。隐孢子虫。感染与WAVZ和LAVZ中0.55的平均下降显著相关.应在公共卫生政策中解决亚临床寄生虫肠道感染与婴儿轻度生长迟缓之间的低估关联。
