关键词: acute exacerbation of COPD chronic obstructive pulmonary disease eosinophils non-invasive mechanical ventilation pharmacological treatment

Mesh : Androstadienes / therapeutic use Antibodies, Monoclonal, Humanized / therapeutic use Benzyl Alcohols / therapeutic use Bronchodilator Agents / therapeutic use Chlorobenzenes / therapeutic use Common Cold Disease Progression Drug Combinations Eosinophils / immunology Glucocorticoids / therapeutic use Haemophilus Infections Humans Interleukin-5 / antagonists & inhibitors immunology Moraxellaceae Infections Muscarinic Antagonists / therapeutic use Noninvasive Ventilation / methods Pulmonary Disease, Chronic Obstructive / immunology microbiology therapy Quinuclidines / therapeutic use Seasons Severity of Illness Index Tiotropium Bromide / therapeutic use

来  源:   DOI:10.1080/15412555.2018.1444022

Abstract:
In this review, we focused on original manuscripts published in the 2017 that provided additional information on the clinical and therapeutic features of the chronic obstructive pulmonary disease (COPD). We have chosen eight of these studies, collected in four topics concerning the pharmacological treatment (tiotropium) of mild-moderate patients, the pharmacological (fluticasone furoate/vilanterol/umeclidinium) and non-pharmacological treatment (non-invasive mechanical ventilation) of severe patients, the etiology of acute exacerbation of COPD involving seasonal airway pathogens and the role of eosinophils with particular interest to the monoclonal antibody directed against interleukin-5 (mepolizumab). For each topic, we report a brief description of studies, take-home messages, and brief comments.
摘要:
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