■骨炎在慢性鼻窦炎伴鼻息肉(CRSwNP)患者中更为普遍,使疾病难治,容易复发。然而,CRS中骨炎形成的病理生理机制尚未完全阐明,本研究旨在进一步阐明CRSwNP患者中嗜酸性粒细胞和2型炎症介质与骨炎的关系。
■这项回顾性研究收集了125例CRSwNP的临床资料。根据鼻窦CT扫描中是否存在骨炎,将参与者分为两组。将各组分为骨炎组和非骨炎组。临床基线数据,2型炎症介质,比较两组患者的嗜酸性粒细胞。还评估了这些因素与全球骨炎评分量表(GOSS)之间的相关性。
■CRSwNP患者骨炎组69例,非骨炎组56例。合并哮喘的患病率(P=0.009),SNOT-22得分,LUND-MAKAY得分,骨炎组LUND-KEDENY评分明显高于非骨炎组(P值均<0.001);IL-13绝对值(P<0.001),骨膜蛋白(P<0.001),与无骨炎组相比,骨炎组组织嗜酸性粒细胞明显升高(P<0.05)。Logistic回归分析显示IL-13和骨膜蛋白是CRSwNP骨炎的危险因素(P<0.001)。ROC曲线分析显示IL-13的预测价值最高(AUC=0.786),截止值为5.8059pg/mL,灵敏度为58.0%,特异性分别为89.3%。
骨炎可能表明慢性鼻窦炎伴鼻息肉(CRSwNP)的症状更严重,和升高的IL-13,骨膜蛋白,和组织嗜酸性粒细胞是CRSwNP患者骨炎形成的危险因素。
UNASSIGNED: Osteitis is more prevalent in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), making the disease refractory and prone to recurrence. However, the pathophysiologic mechanism of osteitis formation in CRS has not been fully elucidated, and this study aimed to further elucidate the association of
eosinophils and type 2 inflammatory mediators with osteitis in patients with CRSwNP.
UNASSIGNED: This retrospective study collected clinical data on 125 cases of CRSwNP. The participants were categorized into two groups based on the presence or absence of osteitis in their sinus CT scan. The groups were classified as the osteitis group and the non-osteitis group. The clinical baseline data, type 2 inflammatory mediators, and
eosinophils were compared between the two groups. The correlation between these factors and the Global Osteitis score scale (GOSS) was also evaluated.
UNASSIGNED: There were 69 cases in the osteitis group and 56 cases in the non-osteitis group of CRSwNP patients. The prevalence of concomitant asthma (P=0.009), SNOT-22 score, LUND-MAKAY score, and LUND-KEDENY score were significantly higher in the osteitis group than in the non-osteitis group (All P values were < 0.001); the absolute values of IL-13 (P<0.001), periosteal proteins (P<0.001), and tissue
eosinophils (P < 0.05) were significantly higher in the osteitis group as compared with the non-osteitis group. Logistic regression analysis showed that IL-13 and periosteal proteins were risk factors for CRSwNP osteitis (P<0.001). ROC curve analysis revealed that IL-13 had the highest predictive value (AUC=0.786) with a cut-off value of 5.8059 pg/mL, the sensitivity of 58.0%, and a specificity of 89.3% respectively.
UNASSIGNED: Osteitis could indicate the more severe symptoms of chronic rhinosinusitis with nasal polyps (CRSwNP), and elevated IL-13, periosteal proteins, and tissue
eosinophils are risk factors for osteitis formation in patients with CRSwNP.