对天然存在的 Muraymycin 核苷抗生素的靶标相互作用的见解。
关键词: activity assays antibiotics natural products nucleosides structure-activity relationships
Mesh : Anti-Bacterial Agents / chemistry pharmacology Bacterial Proteins / antagonists & inhibitors chemistry metabolism Crystallography, X-Ray Escherichia coli / drug effects growth & development Escherichia coli Infections / drug therapy microbiology Humans Molecular Docking Simulation Nucleosides / chemistry pharmacology Nucleotides / chemistry pharmacology Peptides / chemistry pharmacology Staphylococcal Infections / drug therapy microbiology Staphylococcus aureus / drug effects growth & development Structure-Activity Relationship Transferases / antagonists & inhibitors chemistry metabolism Transferases (Other Substituted Phosphate Groups) Urea / chemistry pharmacology
来 源:
DOI:10.1002/cmdc.201700793
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