关键词: Choroidal neovascularization Intravitreal aflibercept Rubella retinopathy

Mesh : Adolescent Choroidal Neovascularization / diagnosis drug therapy etiology Eye Infections, Viral / complications diagnosis Female Fluorescein Angiography Fundus Oculi Humans Intravitreal Injections Receptors, Vascular Endothelial Growth Factor / administration & dosage antagonists & inhibitors Recombinant Fusion Proteins / administration & dosage Retinitis / complications diagnosis virology Rubella / complications diagnosis virology Tomography, Optical Coherence

来  源:   DOI:10.1007/s10792-018-0830-5

Abstract:
OBJECTIVE: To report a case of choroidal neovascularization (CNV) associated with rubella retinopathy (RR) treated with intravitreal aflibercept.
METHODS: A 15-year-old girl presented a complaint of visual decrease in her left eye. She had a history of hearing decrease since she was 1 year old in addition to patent ductus arteriosus. On ocular examination, the best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/400 in the left eye. Dilated fundus examinations revealed a classic salt-and-pepper appearance in both eyes and a whitish subretinal lesion with retinal hemorrhages in the left macula. Fundus fluorescein angiography (FFA) of the left eye illustrated a pattern of diffuse spotty fluorescence with an active subfoveal CNV lesion, that hyperfluoresces in the early phases of the FFA, maintains well-demarcated borders, and leaks. Spectral domain optical coherence tomography (SD-OCT) revealed thickened and elevated retinal layers at the macula due to the subretinal and intraretinal fluid with foveal and extrafoveal protruding hyper-reflective lesion in the left eye. Single dose of intravitreal aflibercept was performed to the left eye and at the first month after the injection, the BCVA improved to 20/100 and the OCT revealed scar formation. At the follow-up visits, the macula was similar to those at the first month post-injection, and the BCVA was preserved. No additional injections were needed.
CONCLUSIONS: Intravitreal aflibercept may be a treatment alternative, which provides satisfactory anatomical and functional results and leads to a better visual acuity in cases with RR complicated by CNV.
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