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Abstract：
The high levels of eicosanoid production and the clinical efficacy of leukotriene-modifying pharmacotherapies for patients with aspirin-exacerbated respiratory disease (AERD) suggest that other interventions targeting arachidonic acid dysregulation may also improve disease control.
To assess the utility of a high omega-3/low omega-6 diet for the treatment of AERD.
Prospective, nonblinded dietary intervention in 10 adult patients with AERD at Brigham and Women\'s Hospital in Boston, MA. The primary objective was for subjects to reduce dietary omega-6 fatty acid consumption to less than 4 g/d and increase omega-3 intake to more than 3 g/d. The primary outcome was change in urinary leukotriene E4, with changes in other eicosanoids, platelet activation, lung function, and patient-reported questionnaires also assessed.
Of the 10 subjects who screened for the study, all 10 completed the dietary intervention. Urinary leukotriene E4 decreased by 0.17 ng/mg (95% CI, -0.29 to -0.04; P = .02) and tetranor prostaglandin D-M decreased by 0.66 ng/mg creatinine (95% CI, -1.21 to -0.11; P = .02). There was a 15.1-point reduction in the 22-item Sino-Nasal Outcome Test score (95% CI, -24.3 to -6.0; P = .01), a 0.27-point reduction in the 7-item Asthma Control Questionnaire score (95% CI, -0.52 to -0.03; P = .03), and no change in FEV1 % predicted (P = .92) or forced vital capacity % predicted (P = .74). All patients lost some weight over the 2-week intervention period, and there were no diet-associated adverse events.
A high omega-3/low omega-6 diet may be an appropriate adjunct treatment option for patients with AERD.
To assess the utility of a high omega-3/low omega-6 diet for the treatment of AERD.
Prospective, nonblinded dietary intervention in 10 adult patients with AERD at Brigham and Women\'s Hospital in Boston, MA. The primary objective was for subjects to reduce dietary omega-6 fatty acid consumption to less than 4 g/d and increase omega-3 intake to more than 3 g/d. The primary outcome was change in urinary leukotriene E4, with changes in other eicosanoids, platelet activation, lung function, and patient-reported questionnaires also assessed.
Of the 10 subjects who screened for the study, all 10 completed the dietary intervention. Urinary leukotriene E4 decreased by 0.17 ng/mg (95% CI, -0.29 to -0.04; P = .02) and tetranor prostaglandin D-M decreased by 0.66 ng/mg creatinine (95% CI, -1.21 to -0.11; P = .02). There was a 15.1-point reduction in the 22-item Sino-Nasal Outcome Test score (95% CI, -24.3 to -6.0; P = .01), a 0.27-point reduction in the 7-item Asthma Control Questionnaire score (95% CI, -0.52 to -0.03; P = .03), and no change in FEV1 % predicted (P = .92) or forced vital capacity % predicted (P = .74). All patients lost some weight over the 2-week intervention period, and there were no diet-associated adverse events.
A high omega-3/low omega-6 diet may be an appropriate adjunct treatment option for patients with AERD.
摘要：
对于阿司匹林加重的呼吸系统疾病（AERD）患者，高水平的类二十烷酸产生和白三烯修饰药物疗法的临床疗效表明，其他针对花生四烯酸失调的干预措施也可能改善疾病控制。
评估高omega-3/低omega-6饮食用于治疗AERD的效用。
预期，在波士顿布莱根妇女医院对10名成人AERD患者进行非盲饮食干预，受试者的主要目标是将饮食中的omega-6脂肪酸摄入量减少到低于4g/d，并将omega-3摄入量增加到超过3g/d。主要结果是尿白三烯E4的变化，其他类二十烷酸的变化，血小板活化,肺功能,和患者报告的问卷也进行了评估。
在筛选这项研究的10名受试者中，所有10人都完成了饮食干预.尿白三烯E4降低了0.17ng/mg（95％CI，-0.29至-0.04；P=.02），而四胺前列腺素D-M降低了0.66ng/mg肌酐（95％CI，-1.21至-0.11；P=.02）。22项鼻中结果测试得分降低了15.1分（95％CI，-24.3至-6.0；P=0.01），7项哮喘控制问卷得分降低0.27分（95％CI，-0.52至-0.03；P=0.03），预测的FEV1%(P=0.92)或预测的强迫肺活量%(P=0.74)没有变化。所有患者在2周的干预期内都减轻了一些体重，并且没有饮食相关的不良事件。
高omega-3/低omega-6饮食可能是AERD患者的适当辅助治疗选择。
评估高omega-3/低omega-6饮食用于治疗AERD的效用。
预期，在波士顿布莱根妇女医院对10名成人AERD患者进行非盲饮食干预，受试者的主要目标是将饮食中的omega-6脂肪酸摄入量减少到低于4g/d，并将omega-3摄入量增加到超过3g/d。主要结果是尿白三烯E4的变化，其他类二十烷酸的变化，血小板活化,肺功能,和患者报告的问卷也进行了评估。
在筛选这项研究的10名受试者中，所有10人都完成了饮食干预.尿白三烯E4降低了0.17ng/mg（95％CI，-0.29至-0.04；P=.02），而四胺前列腺素D-M降低了0.66ng/mg肌酐（95％CI，-1.21至-0.11；P=.02）。22项鼻中结果测试得分降低了15.1分（95％CI，-24.3至-6.0；P=0.01），7项哮喘控制问卷得分降低0.27分（95％CI，-0.52至-0.03；P=0.03），预测的FEV1%(P=0.92)或预测的强迫肺活量%(P=0.74)没有变化。所有患者在2周的干预期内都减轻了一些体重，并且没有饮食相关的不良事件。
高omega-3/低omega-6饮食可能是AERD患者的适当辅助治疗选择。
