PDF(Sci-hub)
Abstract：
Small fiber neuropathy (SFN) is a common disorder leading to neuropathic pain and autonomic symptoms. The objective of this study was to investigate associated conditions in a large cohort of SFN patients and compare the prevalence to healthy individuals.
A total of 921 patients with pure SFN were screened according to a standardized comprehensive diagnostic algorithm and compared with literature findings.
No associated condition could be found in 53% of the patients. Autoimmune diseases, sodium channel gene mutations, diabetes mellitus including glucose intolerance, and vitamin B12 deficiencies were more prevalent than reported literature findings, followed by alcohol abuse, chemotherapy, monoclonal gammopathy of undetermined significance, and haemochromatosis. In patients who were already known with a possible underlying condition at screening, additional underlying conditions were still found in another 26.7% of patients.
Based on these results, it is recommended that patients with pure SFN are screened at least for autoimmune diseases, sodium channel gene mutations, diabetes mellitus including glucose intolerance, and vitamin B12 deficiency, even when they already have a potential underlying condition at referral.
A total of 921 patients with pure SFN were screened according to a standardized comprehensive diagnostic algorithm and compared with literature findings.
No associated condition could be found in 53% of the patients. Autoimmune diseases, sodium channel gene mutations, diabetes mellitus including glucose intolerance, and vitamin B12 deficiencies were more prevalent than reported literature findings, followed by alcohol abuse, chemotherapy, monoclonal gammopathy of undetermined significance, and haemochromatosis. In patients who were already known with a possible underlying condition at screening, additional underlying conditions were still found in another 26.7% of patients.
Based on these results, it is recommended that patients with pure SFN are screened at least for autoimmune diseases, sodium channel gene mutations, diabetes mellitus including glucose intolerance, and vitamin B12 deficiency, even when they already have a potential underlying condition at referral.
摘要：
小纤维神经病(SFN)是导致神经性疼痛和自主神经症状的常见疾病。这项研究的目的是调查大量SFN患者的相关状况，并将患病率与健康个体进行比较。
根据标准化的综合诊断算法筛选了921例纯SFN患者，并与文献结果进行了比较。
53%的患者未发现相关病症。自身免疫性疾病,钠通道基因突变，糖尿病包括葡萄糖耐受不良，维生素B12缺乏比文献报道的结果更为普遍，其次是酗酒，化疗,意义不明的单克隆丙种球蛋白病，和血色素沉着症。在筛查时已知存在潜在疾病的患者中，在另外26.7%的患者中仍发现了其他潜在疾病.
基于这些结果，建议对纯SFN患者至少进行自身免疫性疾病筛查，钠通道基因突变，糖尿病包括葡萄糖耐受不良，维生素B12缺乏,即使他们在转诊时已经有潜在的潜在疾病。
根据标准化的综合诊断算法筛选了921例纯SFN患者，并与文献结果进行了比较。
53%的患者未发现相关病症。自身免疫性疾病,钠通道基因突变，糖尿病包括葡萄糖耐受不良，维生素B12缺乏比文献报道的结果更为普遍，其次是酗酒，化疗,意义不明的单克隆丙种球蛋白病，和血色素沉着症。在筛查时已知存在潜在疾病的患者中，在另外26.7%的患者中仍发现了其他潜在疾病.
基于这些结果，建议对纯SFN患者至少进行自身免疫性疾病筛查，钠通道基因突变，糖尿病包括葡萄糖耐受不良，维生素B12缺乏,即使他们在转诊时已经有潜在的潜在疾病。
