METHODS: Herein we present the cases of two men aged 56 and 23 years presenting SSc without anti-Scl70 or anti-centromere antibodies but with anti-RNA polymerase III antibodies. Clinical symptoms led us to prescribe more laboratory exams and both patients were diagnosed with cancer of the nasopharyngeal area.
CONCLUSIONS: Anti-RNA polymerase III antibodies are useful for SSc diagnosis in patients without anti-centromere or anti-Scl70 antibodies. Their presence must lead physicians to screen for associated cancer, even in the absence of clinical signs.
方法:在此,我们介绍了两名年龄分别为56岁和23岁的男性,他们的SSc没有抗Scl70或抗着丝粒抗体,但有抗RNA聚合酶III抗体。临床症状导致我们开了更多的实验室检查,两名患者都被诊断为鼻咽癌。
结论:在没有抗着丝粒或抗Scl70抗体的患者中,抗RNA聚合酶III抗体可用于SSc诊断。他们的存在必须引导医生筛查相关癌症,即使没有临床症状。