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Abstract：
BACKGROUND: The incidence of cancer is increased in patients with systemic sclerosis (SSc). Further, recent studies have also shown that the presence of anti-RNA polymerase III antibodies is associated with a higher incidence of cancer in this population.
METHODS: Herein we present the cases of two men aged 56 and 23 years presenting SSc without anti-Scl70 or anti-centromere antibodies but with anti-RNA polymerase III antibodies. Clinical symptoms led us to prescribe more laboratory exams and both patients were diagnosed with cancer of the nasopharyngeal area.
CONCLUSIONS: Anti-RNA polymerase III antibodies are useful for SSc diagnosis in patients without anti-centromere or anti-Scl70 antibodies. Their presence must lead physicians to screen for associated cancer, even in the absence of clinical signs.
METHODS: Herein we present the cases of two men aged 56 and 23 years presenting SSc without anti-Scl70 or anti-centromere antibodies but with anti-RNA polymerase III antibodies. Clinical symptoms led us to prescribe more laboratory exams and both patients were diagnosed with cancer of the nasopharyngeal area.
CONCLUSIONS: Anti-RNA polymerase III antibodies are useful for SSc diagnosis in patients without anti-centromere or anti-Scl70 antibodies. Their presence must lead physicians to screen for associated cancer, even in the absence of clinical signs.
摘要：
背景：系统性硬化症（SSc）患者的癌症发病率增加。Further,最近的研究还表明,在该人群中,抗RNA聚合酶III抗体的存在与较高的癌症发病率相关.
方法：在此，我们介绍了两名年龄分别为56岁和23岁的男性，他们的SSc没有抗Scl70或抗着丝粒抗体，但有抗RNA聚合酶III抗体。临床症状导致我们开了更多的实验室检查，两名患者都被诊断为鼻咽癌。
结论：在没有抗着丝粒或抗Scl70抗体的患者中，抗RNA聚合酶III抗体可用于SSc诊断。他们的存在必须引导医生筛查相关癌症，即使没有临床症状。
方法：在此，我们介绍了两名年龄分别为56岁和23岁的男性，他们的SSc没有抗Scl70或抗着丝粒抗体，但有抗RNA聚合酶III抗体。临床症状导致我们开了更多的实验室检查，两名患者都被诊断为鼻咽癌。
结论：在没有抗着丝粒或抗Scl70抗体的患者中，抗RNA聚合酶III抗体可用于SSc诊断。他们的存在必须引导医生筛查相关癌症，即使没有临床症状。
