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Abstract：
OBJECTIVE: The aim of the present study was to investigate the clinical performance of self-assembling peptide P11 -4 on non-cavitated initial proximal carious lesions 12 months after treatment.
METHODS: Twenty-six patients, aged between 18 and 65 years, with 35 carious lesions were included in this practice-based, uncontrolled, prospective case series. The opacity and size of the proximal lesions were evaluated visually at baseline and at day 360 using standardized single-tooth or bite-wing and digital-subtraction radiography. Pairwise evaluation of images was carried out in a randomized and blinded manner with respect to the time point.
RESULTS: Twelve months after treatment of the proximal carious lesions, the visual evaluation showed a predominant shift toward regression of the initial lesions. Radiographic assessment yielded regression of the caries in 17 of 28 cases; four of 28 were regarded as unchanged, and seven of 28 lesions showed progression of the carious lesion. Combined assessment of clinical radiographs and digital subtraction radiographs confirmed the radiographic assessment, with 20 of 28 lesions showing total or partial regression, four unchanged, and four progressing.
CONCLUSIONS: Radiographic and digital subtraction analyses suggest that initial proximal carious lesions can regress after treatment with P11 -4, but additional factors might influence the overall treatment outcome.
METHODS: Twenty-six patients, aged between 18 and 65 years, with 35 carious lesions were included in this practice-based, uncontrolled, prospective case series. The opacity and size of the proximal lesions were evaluated visually at baseline and at day 360 using standardized single-tooth or bite-wing and digital-subtraction radiography. Pairwise evaluation of images was carried out in a randomized and blinded manner with respect to the time point.
RESULTS: Twelve months after treatment of the proximal carious lesions, the visual evaluation showed a predominant shift toward regression of the initial lesions. Radiographic assessment yielded regression of the caries in 17 of 28 cases; four of 28 were regarded as unchanged, and seven of 28 lesions showed progression of the carious lesion. Combined assessment of clinical radiographs and digital subtraction radiographs confirmed the radiographic assessment, with 20 of 28 lesions showing total or partial regression, four unchanged, and four progressing.
CONCLUSIONS: Radiographic and digital subtraction analyses suggest that initial proximal carious lesions can regress after treatment with P11 -4, but additional factors might influence the overall treatment outcome.
摘要：
目的：本研究的目的是研究自组装肽P11-4在治疗后12个月的非空化初始近端龋齿病变上的临床表现。
方法：26名患者，年龄在18至65岁之间，有35个龋齿病变被包括在这个实践的基础上，不受控制,前瞻性病例系列。在基线和第360天，使用标准化的单齿或咬合翼和数字减影射线照相术对近端病变的不透明度和大小进行了视觉评估。以相对于时间点的随机化和盲化方式进行图像的成对评估。
结果：治疗近端龋齿病变12个月后，视觉评估显示,初始病变主要向消退转移.影像学评估显示28例中有17例的龋齿消退；28例中有4例被认为没有变化，28个病变中有7个显示龋齿病变进展。临床X光片和数字减影X光片的联合评估证实了影像学评估，28个病变中有20个显示完全或部分消退，四个不变,四是进步。
结论：影像学和数字减影分析表明，P11-4治疗后，早期的近端龋病变可能会消退，但其他因素可能会影响整体治疗结果。
方法：26名患者，年龄在18至65岁之间，有35个龋齿病变被包括在这个实践的基础上，不受控制,前瞻性病例系列。在基线和第360天，使用标准化的单齿或咬合翼和数字减影射线照相术对近端病变的不透明度和大小进行了视觉评估。以相对于时间点的随机化和盲化方式进行图像的成对评估。
结果：治疗近端龋齿病变12个月后，视觉评估显示,初始病变主要向消退转移.影像学评估显示28例中有17例的龋齿消退；28例中有4例被认为没有变化，28个病变中有7个显示龋齿病变进展。临床X光片和数字减影X光片的联合评估证实了影像学评估，28个病变中有20个显示完全或部分消退，四个不变,四是进步。
结论：影像学和数字减影分析表明，P11-4治疗后，早期的近端龋病变可能会消退，但其他因素可能会影响整体治疗结果。
