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Abstract：
Impaired sexual function has a significant effect on quality of life. Various patient-reported outcome measures (PROMs) are available to evaluate sexual function. The quality of the PROMs to be used for neurologic patients remains unknown.
To systematically review which validated PROMs are available to evaluate sexual function in neurologic patients and to critically assess the quality of the validation studies and measurement properties for each identified PROM.
A systematic review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. The included publications were assessed according to the Consensus-Based Standards for the Selection of Health Measurement Instruments checklist.
Twenty-one studies for PROMs regarding sexual function were identified for the following patient groups: spinal cord injury (11 studies), multiple sclerosis (MS; 6 studies), Parkinson\'s disease (2 studies), traumatic brain injury (1 study), and epilepsy (1 study). The evidence for the quality of PROMs was found to be variable, and overall evaluation of measurement properties was lacking in 71% of the studies. The measurement error and responsiveness were not studied in any of the publications.
Several PROMs have been identified to evaluate sexual function in neurologic patients. Strong evidence was found only for the Multiple Sclerosis Intimacy and Sexuality Questionnaire-15 and Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 for patients with MS, although evidence was lacking for certain measurement properties as well. Future research should focus on identifying relevant PROMs and establishing adequate quality for all measurement properties in studies with high methodological quality.
A quality assessment of patient-reported outcome measures (PROMs) for sexual function in neurologic patients was made. The evidence found for good PROMs was limited. Studies with high methodological quality are needed to improve the quality of PROMs to evaluate sexual function in neurologic patients.
To systematically review which validated PROMs are available to evaluate sexual function in neurologic patients and to critically assess the quality of the validation studies and measurement properties for each identified PROM.
A systematic review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. The included publications were assessed according to the Consensus-Based Standards for the Selection of Health Measurement Instruments checklist.
Twenty-one studies for PROMs regarding sexual function were identified for the following patient groups: spinal cord injury (11 studies), multiple sclerosis (MS; 6 studies), Parkinson\'s disease (2 studies), traumatic brain injury (1 study), and epilepsy (1 study). The evidence for the quality of PROMs was found to be variable, and overall evaluation of measurement properties was lacking in 71% of the studies. The measurement error and responsiveness were not studied in any of the publications.
Several PROMs have been identified to evaluate sexual function in neurologic patients. Strong evidence was found only for the Multiple Sclerosis Intimacy and Sexuality Questionnaire-15 and Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 for patients with MS, although evidence was lacking for certain measurement properties as well. Future research should focus on identifying relevant PROMs and establishing adequate quality for all measurement properties in studies with high methodological quality.
A quality assessment of patient-reported outcome measures (PROMs) for sexual function in neurologic patients was made. The evidence found for good PROMs was limited. Studies with high methodological quality are needed to improve the quality of PROMs to evaluate sexual function in neurologic patients.
摘要：
性功能受损对生活质量有显著影响。各种患者报告的结果测量（PROM）可用于评估性功能。用于神经系统患者的PROM的质量仍然未知。
系统回顾哪些验证的PROM可用于评估神经系统患者的性功能，并严格评估每个已确定的PROM的验证研究和测量特性的质量。
根据系统评价和荟萃分析报表的首选报告项目进行系统评价。根据基于共识的健康测量仪器选择标准清单对纳入的出版物进行评估。
针对以下患者组确定了21项有关性功能的PROM研究：脊髓损伤（11项研究），多发性硬化症（MS；6项研究），帕金森病（2项研究），创伤性脑损伤（1项研究），癫痫（1项研究）。发现PROM质量的证据是可变的，71%的研究缺乏对测量特性的总体评估。在任何出版物中都没有研究测量误差和响应性。
已经确定了几种PROM来评估神经系统患者的性功能。只有针对MS患者的多发性硬化亲密关系和性行为问卷-15和多发性硬化亲密关系和性行为问卷-19的有力证据，尽管某些测量特性也缺乏证据。未来的研究应侧重于确定相关的PROM，并在具有高方法学质量的研究中为所有测量特性建立足够的质量。
对神经科患者性功能的患者报告结果测量（PROMs）进行质量评估。发现的良好PROM的证据有限。需要具有高方法学质量的研究来提高PROM的质量，以评估神经系统患者的性功能。
系统回顾哪些验证的PROM可用于评估神经系统患者的性功能，并严格评估每个已确定的PROM的验证研究和测量特性的质量。
根据系统评价和荟萃分析报表的首选报告项目进行系统评价。根据基于共识的健康测量仪器选择标准清单对纳入的出版物进行评估。
针对以下患者组确定了21项有关性功能的PROM研究：脊髓损伤（11项研究），多发性硬化症（MS；6项研究），帕金森病（2项研究），创伤性脑损伤（1项研究），癫痫（1项研究）。发现PROM质量的证据是可变的，71%的研究缺乏对测量特性的总体评估。在任何出版物中都没有研究测量误差和响应性。
已经确定了几种PROM来评估神经系统患者的性功能。只有针对MS患者的多发性硬化亲密关系和性行为问卷-15和多发性硬化亲密关系和性行为问卷-19的有力证据，尽管某些测量特性也缺乏证据。未来的研究应侧重于确定相关的PROM，并在具有高方法学质量的研究中为所有测量特性建立足够的质量。
对神经科患者性功能的患者报告结果测量（PROMs）进行质量评估。发现的良好PROM的证据有限。需要具有高方法学质量的研究来提高PROM的质量，以评估神经系统患者的性功能。
