侵袭性念珠菌病是一种严重的感染形式。侵袭性真菌感染的发生率有所增加,由于越来越多的免疫力受损患者因长期住院而接受治疗。神经系统患者的治疗方法,如抗菌药物,皮质类固醇,中心静脉导管(CVC),全胃肠外营养,机械通气的使用与侵袭性念珠菌病的常见危险因素相关。我们的研究表明,神经系统患者中侵袭性念珠菌病的患病率。
对2017年1月至2020年2月在印度尼西亚东雅加达MaharMardjono国家脑中心医院住院的神经系统患者进行了一项横断面研究。败血症患者,感染性休克,或发烧(>38.5°C),并且在培养前没有接受抗真菌药物的患者被纳入研究。临床标本取自血液,白酒脑脊液或其他无菌部位,CVC,呼吸道标本,和尿液或其他非无菌部位。社会人口统计数据,基于先前研究的潜在风险因素,临床,和其他测试数据是从医疗记录中获得的。侵袭性念珠菌病的分类是根据Paphitou分类标准进行的。
一百零二名受试者符合研究标准。神经系统患者侵袭性念珠菌病的患病率为13.7%。所有的分离株都是近平滑梭菌。
在所研究的样本中,侵袭性念珠菌病的患病率很高。感染与感染性休克有关,气管造口术,和使用中心静脉导管的持续时间,呼吸机,和类固醇。
Invasive candidiasis is a severe form of infection. The incidence of invasive fungal infections has increased, due to the increasing number of patients with impaired immunity who are being treated through prolonged stay in hospital facilities. Neurological patient treatment methods such as antimicrobials, corticosteroid, central venous catheter (CVC), total parenteral nutrition, and mechanical ventilation use are associated with common risk factors for invasive candidiasis. Our study demonstrated invasive candidiasis prevalence among neurological patients.
A cross-sectional study was done with consecutive sampling of neurological patients who were hospitalized from January 2017 to February 2020 at the Mahar Mardjono National Brain Center Hospital East Jakarta Indonesia. Patients with sepsis, septic shock, or fever (> 38.5 °C), and who had not received antifungals before culture were enrolled in the study. Clinical specimens were obtained from blood, liquor cerebrospinal or other sterile sites, CVC, respiratory tract specimens, and urine or other non-sterile sites. Socio-demographic data, potential risk factors based on previous studies, clinical, and other tests data were obtained from medical records. Classification of invasive candidiasis was according to the Paphitou classification criteria.
One hundred and two subjects met the study criteria. The prevalence of invasive candidiasis in neurological patients was 13.7%. All of the isolates were C. parapsilosis.
The prevalence of invasive candidiasis was high in the samples studied. The infection was associated with septic shock, tracheostomy, and duration of use of central venous catheter, ventilator, and steroids.