Abstract：
OBJECTIVE: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE).
METHODS: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups.
RESULTS: Data from 52 Roma and 98 Caucasian SLE patients were included. Roma SLE patients had a higher risk (odds ratio 2.56, 95% CI 1.02-6.39) and prevalence of APS (28.8% vs. 13.3%, P = 0.027). Furthermore, Roma SLE patients had a statistically significant higher prevalence of abortions (23.5% vs. 10.2%, P = 0.049). In relation to other APS diagnostic criteria, Roma SLE patients had a non-statistically significant higher prevalence of fetal deaths (14.3% vs. 5.1%, P = 0.106) and thrombotic events (21.1% vs. 12.2%, P = 0.160). In relation to SLE clinical features, Roma patients had a significantly higher prevalence of arthritis (75% vs. 57.1%, P = 0.034) and non-significant higher prevalence of serositis (44.2% vs. 29.6%, P = 0.104), discoid lesions (11.5% vs. 5.1%, P = 0.191), oral ulcers (46.1% vs. 34.7%, P = 0.218) and livedo reticularis (21.1% vs. 15.3%, P = 0.374). No statistically significant differences were found in the Systemic Lupus International Collaborating Clinics Damage Index or the autoimmune serological profile.
CONCLUSIONS: Prevalence and risk of APS were significantly higher in Roma SLE patients. Furthermore, Roma patients had a significantly higher prevalence of abortions and a non-significant higher prevalence of fetal deaths and thrombotic events.
METHODS: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups.
RESULTS: Data from 52 Roma and 98 Caucasian SLE patients were included. Roma SLE patients had a higher risk (odds ratio 2.56, 95% CI 1.02-6.39) and prevalence of APS (28.8% vs. 13.3%, P = 0.027). Furthermore, Roma SLE patients had a statistically significant higher prevalence of abortions (23.5% vs. 10.2%, P = 0.049). In relation to other APS diagnostic criteria, Roma SLE patients had a non-statistically significant higher prevalence of fetal deaths (14.3% vs. 5.1%, P = 0.106) and thrombotic events (21.1% vs. 12.2%, P = 0.160). In relation to SLE clinical features, Roma patients had a significantly higher prevalence of arthritis (75% vs. 57.1%, P = 0.034) and non-significant higher prevalence of serositis (44.2% vs. 29.6%, P = 0.104), discoid lesions (11.5% vs. 5.1%, P = 0.191), oral ulcers (46.1% vs. 34.7%, P = 0.218) and livedo reticularis (21.1% vs. 15.3%, P = 0.374). No statistically significant differences were found in the Systemic Lupus International Collaborating Clinics Damage Index or the autoimmune serological profile.
CONCLUSIONS: Prevalence and risk of APS were significantly higher in Roma SLE patients. Furthermore, Roma patients had a significantly higher prevalence of abortions and a non-significant higher prevalence of fetal deaths and thrombotic events.
摘要：
目的：为了确定抗磷脂综合征（APS）的患病率是否存在种族差异，系统性红斑狼疮(SLE)患者罗姆和白种人的临床表现和自身抗体谱.
方法：进行了一项横断面研究，包括连续在西班牙六家医院就诊的罗姆人和白种人SLE患者的数据。社会人口特征，APS的患病率，在不同种族之间比较了SLE和APS的临床和分析特征.
结果：纳入52例罗姆人和98名白种人SLE患者的数据。RomaSLE患者的APS风险较高（比值比2.56，95％CI1.02-6.39）和患病率较高（28.8％vs.13.3%,P=0.027)。此外，RomaSLE患者的流产患病率在统计学上显着较高（23.5％vs.10.2%,P=0.049)。关于其他APS诊断标准，罗马SLE患者的胎儿死亡发生率无统计学意义（14.3％vs.5.1%,P=0.106）和血栓事件（21.1%vs.12.2%,P=0.160）。关于SLE临床特征，罗马患者的关节炎患病率明显较高（75％vs.57.1%,P=0.034)和非显著较高的浆膜炎患病率(44.2%vs.29.6%,P=0.104),盘状病变（11.5%vs.5.1%,P=0.191),口腔溃疡（46.1%vs.34.7%,P=0.218）和网状livedo（21.1%vs.15.3%,P=0.374）。在系统性狼疮国际合作诊所损害指数或自身免疫血清学特征中没有发现统计学上的显着差异。
结论：在RomaSLE患者中，APS的患病率和风险显著增高。此外，罗姆患者的流产患病率明显较高，而胎儿死亡和血栓事件的患病率则不明显。
方法：进行了一项横断面研究，包括连续在西班牙六家医院就诊的罗姆人和白种人SLE患者的数据。社会人口特征，APS的患病率，在不同种族之间比较了SLE和APS的临床和分析特征.
结果：纳入52例罗姆人和98名白种人SLE患者的数据。RomaSLE患者的APS风险较高（比值比2.56，95％CI1.02-6.39）和患病率较高（28.8％vs.13.3%,P=0.027)。此外，RomaSLE患者的流产患病率在统计学上显着较高（23.5％vs.10.2%,P=0.049)。关于其他APS诊断标准，罗马SLE患者的胎儿死亡发生率无统计学意义（14.3％vs.5.1%,P=0.106）和血栓事件（21.1%vs.12.2%,P=0.160）。关于SLE临床特征，罗马患者的关节炎患病率明显较高（75％vs.57.1%,P=0.034)和非显著较高的浆膜炎患病率(44.2%vs.29.6%,P=0.104),盘状病变（11.5%vs.5.1%,P=0.191),口腔溃疡（46.1%vs.34.7%,P=0.218）和网状livedo（21.1%vs.15.3%,P=0.374）。在系统性狼疮国际合作诊所损害指数或自身免疫血清学特征中没有发现统计学上的显着差异。
结论：在RomaSLE患者中，APS的患病率和风险显著增高。此外，罗姆患者的流产患病率明显较高，而胎儿死亡和血栓事件的患病率则不明显。
