%0 Comparative Study
%T Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study.
%A Manzano-Gamero V
%A Pardo-Cabello AJ
%A Vargas-Hitos JA
%A Zamora-Pasadas M
%A Navarrete-Navarrete N
%A Sabio JM
%A Jáimez-Gámiz L
%A Ríos-Fernandez R
%A Ortego-Centeno N
%A Ayala-Gutierrez MM
%A de Ramón E
%A Colodro-Ruíz A
%A Micó-Giner L
%A Castillo-Palma MJ
%A Robles-Marhuenda Á
%A Luna-Del Castillo JD
%A Jiménez-Alonso J
%A  
%J Int J Rheum Dis
%V 21
%N 11
%D Nov 2018
%M 28593703
%F 2.558
%R 10.1111/1756-185X.13117
%X <B>OBJECTIVE: </B>To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE).<BR><B>METHODS: </B>A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups.<BR><B>RESULTS: </B>Data from 52 Roma and 98 Caucasian SLE patients were included. Roma SLE patients had a higher risk (odds ratio 2.56, 95% CI 1.02-6.39) and prevalence of APS (28.8% vs. 13.3%, P = 0.027). Furthermore, Roma SLE patients had a statistically significant higher prevalence of abortions (23.5% vs. 10.2%, P = 0.049). In relation to other APS diagnostic criteria, Roma SLE patients had a non-statistically significant higher prevalence of fetal deaths (14.3% vs. 5.1%, P = 0.106) and thrombotic events (21.1% vs. 12.2%, P = 0.160). In relation to SLE clinical features, Roma patients had a significantly higher prevalence of arthritis (75% vs. 57.1%, P = 0.034) and non-significant higher prevalence of serositis (44.2% vs. 29.6%, P = 0.104), discoid lesions (11.5% vs. 5.1%, P = 0.191), oral ulcers (46.1% vs. 34.7%, P = 0.218) and livedo reticularis (21.1% vs. 15.3%, P = 0.374). No statistically significant differences were found in the Systemic Lupus International Collaborating Clinics Damage Index or the autoimmune serological profile.<BR><B>CONCLUSIONS: </B>Prevalence and risk of APS were significantly higher in Roma SLE patients. Furthermore, Roma patients had a significantly higher prevalence of abortions and a non-significant higher prevalence of fetal deaths and thrombotic events.