关键词: Anticancer Apoptosis Cell membrane receptors Ruthenium complex Structure-activity relationship
Mesh : Animals Antineoplastic Agents / pharmacokinetics pharmacology Apoptosis / drug effects Caspases / metabolism Cell Line, Tumor Cell Membrane / metabolism Cell Proliferation / drug effects Cisplatin / pharmacology Coordination Complexes / pharmacokinetics pharmacology DNA Damage Endocytosis Humans Mice, Nude Models, Biological Neoplasms / pathology Phosphorylation / drug effects Pyridines / pharmacokinetics pharmacology Reactive Oxygen Species / metabolism Receptors, Death Domain / metabolism Receptors, Transferrin / metabolism Ruthenium / chemistry pharmacokinetics pharmacology Spheroids, Cellular / drug effects metabolism Tissue Distribution / drug effects Tumor Suppressor Protein p53 / metabolism
来 源:
DOI:10.1016/j.biomaterials.2017.03.017
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