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Abstract：
The esoteric anti-obesity effects of hyacinth bean (Dolichos lablab L) have largely remained unexplored. Herein, we investigated the anti-obesity mechanisms of hyacinth bean compared to milk thistle, a natural herb employed for ameliorating obesity-related diseases, using high-fat diet (HFD) fed mice towards unfolding the perplexing mechanisms.
C57BL/6J mice were orally administered hyacinth bean (25 mg/kg/day) and milk thistle (100 mg/kg/day) for 9 weeks along with HFD. Intriguingly, a number of anti-obesity mechanisms indexed through clinical parameters, suppression in weight gains and liver steatosis were found similar to some disparity. Furthermore, the corresponding metabolic implications were studied through MS-based metabolite profiling, and using the Kyoto Encyclopedia of Genes and Genomes for metabolic pathways revealing that hyacinth bean or milk thistle administration effectively attenuates the HFD-induced lipid, glucose, and bile acid metabolism, with former specifically attenuates pyruvate-derived amino acids metabolism. Among them, valine, asparagine, and lysine displayed high correlation with blood clinical parameters.
A lower dose of hyacinth bean resulted in similar anti-obesity effects as milk thistle, as confirmed by both clinical and metabolomics analyses. Equivocally, we conjecture that hyacinth bean could be used as a potent anti-obesity herbal functional food.
C57BL/6J mice were orally administered hyacinth bean (25 mg/kg/day) and milk thistle (100 mg/kg/day) for 9 weeks along with HFD. Intriguingly, a number of anti-obesity mechanisms indexed through clinical parameters, suppression in weight gains and liver steatosis were found similar to some disparity. Furthermore, the corresponding metabolic implications were studied through MS-based metabolite profiling, and using the Kyoto Encyclopedia of Genes and Genomes for metabolic pathways revealing that hyacinth bean or milk thistle administration effectively attenuates the HFD-induced lipid, glucose, and bile acid metabolism, with former specifically attenuates pyruvate-derived amino acids metabolism. Among them, valine, asparagine, and lysine displayed high correlation with blood clinical parameters.
A lower dose of hyacinth bean resulted in similar anti-obesity effects as milk thistle, as confirmed by both clinical and metabolomics analyses. Equivocally, we conjecture that hyacinth bean could be used as a potent anti-obesity herbal functional food.
摘要：
风信子豆（DolichoslablabL）的深奥抗肥胖作用在很大程度上仍未得到探索。在这里，我们调查了风信子豆与牛奶蓟相比的抗肥胖机制，一种用于改善肥胖相关疾病的天然草药，使用高脂肪饮食（HFD）喂养小鼠，以展开复杂的机制。
将C57BL/6J小鼠与HFD一起口服施用风信子豆(25mg/kg/天)和水飞蓟(100mg/kg/天)9周。有趣的是，通过临床参数索引的许多抗肥胖机制，发现体重增加和肝脏脂肪变性的抑制类似于一些差异。此外，通过基于MS的代谢物谱分析研究了相应的代谢含义，并使用京都基因和基因组百科全书的代谢途径揭示了风信子豆或水飞蓟能有效地减弱HFD诱导的脂质，葡萄糖，和胆汁酸代谢，与前者特异性减弱丙酮酸衍生的氨基酸代谢。其中,缬氨酸,天冬酰胺,赖氨酸与血液临床参数呈高度相关。
较低剂量的风信子豆具有与牛奶蓟相似的抗肥胖作用，正如临床和代谢组学分析所证实的那样。同样,我们推测风信子豆可以用作有效的抗肥胖草药功能食品。
将C57BL/6J小鼠与HFD一起口服施用风信子豆(25mg/kg/天)和水飞蓟(100mg/kg/天)9周。有趣的是，通过临床参数索引的许多抗肥胖机制，发现体重增加和肝脏脂肪变性的抑制类似于一些差异。此外，通过基于MS的代谢物谱分析研究了相应的代谢含义，并使用京都基因和基因组百科全书的代谢途径揭示了风信子豆或水飞蓟能有效地减弱HFD诱导的脂质，葡萄糖，和胆汁酸代谢，与前者特异性减弱丙酮酸衍生的氨基酸代谢。其中,缬氨酸,天冬酰胺,赖氨酸与血液临床参数呈高度相关。
较低剂量的风信子豆具有与牛奶蓟相似的抗肥胖作用，正如临床和代谢组学分析所证实的那样。同样,我们推测风信子豆可以用作有效的抗肥胖草药功能食品。
