PDF(Sci-hub)
Abstract：
BACKGROUND: Apoptotic dysregulation plays a role in the pathogenesis of polycystic ovary syndrome (PCOS).
OBJECTIVE: To evaluate circulatory apoptotic markers and oxidative stress in patients with PCOS.
METHODS: Forty-four women with PCOS, and 44 healthy women as controls were enrolled in the study. Oxidative stress parameters and caspases levels were measured in serum.
RESULTS: The caspase 9 level was significantly lower and related with oxidant status in patients with PCOS, while the circulating levels of caspases 3 and 7 were statistically similar in both groups.
CONCLUSIONS: This study is the first report demonstrating the circulating levels of apoptotic markers and their relationship with oxidant status in PCOS.
CONCLUSIONS: The circulating caspase 9 and oxidant status might contribute to apoptotic dysregulation in PCOS.
OBJECTIVE: To evaluate circulatory apoptotic markers and oxidative stress in patients with PCOS.
METHODS: Forty-four women with PCOS, and 44 healthy women as controls were enrolled in the study. Oxidative stress parameters and caspases levels were measured in serum.
RESULTS: The caspase 9 level was significantly lower and related with oxidant status in patients with PCOS, while the circulating levels of caspases 3 and 7 were statistically similar in both groups.
CONCLUSIONS: This study is the first report demonstrating the circulating levels of apoptotic markers and their relationship with oxidant status in PCOS.
CONCLUSIONS: The circulating caspase 9 and oxidant status might contribute to apoptotic dysregulation in PCOS.
摘要：
背景：细胞凋亡失调在多囊卵巢综合征（PCOS）的发病机制中起作用。
目的：评估PCOS患者的循环凋亡标志物和氧化应激。
方法：44名PCOS患者，44名健康女性作为对照纳入研究。在血清中测量氧化应激参数和半胱天冬酶水平。
结果：PCOS患者caspase9水平明显降低，且与氧化状态有关，而两组的caspases3和7的循环水平在统计学上相似。
结论：本研究首次报道了PCOS中凋亡标志物的循环水平及其与氧化状态的关系。
结论：循环caspase9和氧化状态可能导致PCOS细胞凋亡失调。
目的：评估PCOS患者的循环凋亡标志物和氧化应激。
方法：44名PCOS患者，44名健康女性作为对照纳入研究。在血清中测量氧化应激参数和半胱天冬酶水平。
结果：PCOS患者caspase9水平明显降低，且与氧化状态有关，而两组的caspases3和7的循环水平在统计学上相似。
结论：本研究首次报道了PCOS中凋亡标志物的循环水平及其与氧化状态的关系。
结论：循环caspase9和氧化状态可能导致PCOS细胞凋亡失调。
